Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial
Barnosky A, Kroeger CM, Trepanowski JF, Klempel MC, Bhutani S, Hoddy KK, Gabel K, Shapses SA, Varady KA
Nutrition and healthy aging · 30 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- University or hospital
- University of Illinois at Chicago
- Government
- National Heart, Lung, and Blood Institute
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIDDK NIH HHS
- Grants
- National Institute of Diabetes and Digestive and Kidney Diseases (F32DK107157); National Heart, Lung, and Blood Institute (#T32 HL007034); National Heart, Lung, and Blood Institute (R01 HL); National Institute of Diabetes and Digestive and Kidney Diseases (P30 DK-072476); National Institutes of Health (T32HL007034); National Institutes of Health (F32DK107157)
Based on 5 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2017-10-29 · Nutr Healthy Aging · vol. 4 · issue 3 · pp. 255–263
- Publisher
- IOS Press
- Cited
- 43 citations · more than 83% of similar papers · 1.6× the field average
- References
- 36 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Genetics, Aging, and Longevity in Model Organisms
- Keywords
- Osteocalcin, Internal medicine, Bone remodeling, Endocrinology, Overweight, Bone mineral, Medicine, Randomized controlled trial, N-terminal telopeptide, Weight loss, Calorie restriction, Alkaline phosphatase, Body mass index, Obesity, Chemistry, Osteoporosis, Biochemistry
9 authors
From US
- Adrienne BarnoskyWheaton Franciscan Healthcare; University of Illinois Chicago
- Cynthia M. KroegerUniversity of Alabama at Birmingham; University of Illinois Chicago
- John F. TrepanowskiUniversity of Illinois Chicago; Stanford University
- Monica C KlempelUniversity of Illinois Chicago
- Surabhi BhutaniUniversity of Illinois Chicago
- Kristin K. HoddyUniversity of Illinois Chicago
Abstract
Background
Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown.
Objective
This study examined the impact of ADF versus traditional daily calorie restriction (CR) on markers of bone metabolism in a 6-month randomized controlled trial.
Methods
Overweight and obese subjects (n = 100) were randomized to 1 of 3 groups for 6 months: 1) ADF (25% energy intake fast day, alternated with 125% intake feast day; 2) CR (75% intake every day); or 3) control (usual intake every day).
Results
Body weight decreased similarly (P P < 0.01) in the CR group, with no change in the ADF or control group. When the data were sub-analyzed according to menopausal status, there were no differences between premenopausal or postmenopausal women for any marker of bone metabolism.
Conclusion
These findings suggest that 6 months of ADF does not have any deleterious impact on markers of bone metabolism in obese adults with moderate weight loss.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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