Dietary nitrate-induced increases in human muscle power: high versus low responders
Coggan AR, Broadstreet SR, Mikhalkova D, Bole I, Leibowitz JL, Kadkhodayan A, Park S, Thomas DP, Thies D, Peterson LR
Physiological reports · 61 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Foundation for Barnes-Jewish Hospital
- University or hospital
- Institute of Clinical and Translational Sciences
- Government
- National Institutes of Health
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- National Center for Advancing Translational Sciences
- Government
- NIDDK NIH HHS
- Government
- NCATS NIH HHS
- University or hospital
- Washington University Institute of Clinical and Translational Sciences
- University or hospital
- Washington University Mentors in Medicine and C-STAR programs
- Grants
- Institute of Clinical and Translational Sciences (UL1TR000448); National Institute of Diabetes and Digestive and Kidney Diseases (P30-DK056341); National Center for Advancing Translational Sciences (UL1-TR-000448); Foundation for Barnes-Jewish Hospital (UL1 TR000448); National Center for Advancing Translational Sciences (UL1TR002345); National Center for Advancing Translational Sciences (TR000448); National Institutes of Health (UL1‐TR000448); National Institutes of Health (TR000448)
Based on 9 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Physiol Rep · vol. 6 · issue 2 · p. e13575
- Publisher
- Wiley
- Cited
- 70 citations · more than 99% of similar papers · 10.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 41 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cardiovascular and exercise physiology · Exercise and Physiological Responses · Muscle metabolism and nutrition
- Keywords
- Placebo, Crossover study, Medicine, Internal medicine, Nitric oxide, Body mass index, Bioavailability, Dietary Nitrate, Endocrinology, Nitrite, Animal science, Cardiology, Nitrate, Chemistry, Biology, Pharmacology, Pathology
- MeSH
- humans, beta vulgaris, plant roots, nitrates, nitric oxide, cross-over studies, double-blind method, dietary supplements, adult, aged, middle aged, female, male, athletic performance, muscle fibers, skeletal, young adult, fruit and vegetable juices
10 authors
From US
- Andrew R. Coggan · correspondingUniversity of Indianapolis; Washington University in St. Louis; Indiana University – Purdue University Indianapolis
- Seth R. BroadstreetUniversity of Indianapolis; Indiana University – Purdue University Indianapolis
- Deana MikhalkovaWashington University in St. Louis
- Indra BoleWashington University in St. Louis
- Joshua L. LeibowitzWashington University in St. Louis
- Ana KadkhodayanWashington University in St. Louis
Abstract
Maximal neuromuscular power is an important determinant of athletic performance and also quality of life, independence, and perhaps even mortality in patient populations. We have shown that dietary nitrate (NO3- ), a source of nitric oxide (NO), improves muscle power in some, but not all, subjects. The present investigation was designed to identify factors contributing to this interindividual variability. Healthy men (n = 13) and women (n = 7) 22-79 year of age and weighing 52.1-114.9 kg were studied using a randomized, double-blind, placebo-controlled, crossover design. Subjects were tested 2 h after ingesting beetroot juice (BRJ) either containing or devoid of 12.3 ± 0.8 mmol of NO3- . Plasma NO3- and nitrite (NO2- ) were measured as indicators of NO bioavailability and maximal knee extensor speed (Vmax ), power (Pmax ), and fatigability were determined via isokinetic dynamometry. On average, dietary NO3- increased (P max by 4.4 ± 8.1%. Individual changes, however, ranged from -9.6 to +26.8%. This interindividual variability was not significantly correlated with age, body mass (inverse of NO3- dose per kg), body mass index (surrogate for body composition) or placebo trial Vmax or fatigue index (in vivo indicators of muscle fiber type distribution). In contrast, the relative increase in Pmax was significantly correlated (r = 0.60; P 2- concentration. In multivariable analysis female sex also tended (P = 0.08) to be associated with a greater increase in Pmax. We conclude that the magnitude of the dietary NO3- -induced increase in muscle power is dependent upon the magnitude of the resulting increase in plasma NO2- and possibly female sex.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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