A Randomized Double-Blinded, Placebo-Controlled Trial Investigating the Effect of Fish Oil Supplementation on Gene Expression Related to Insulin Action, Blood Lipids, and Inflammation in Gestational Diabetes Mellitus-Fish Oil Supplementation and Gestational Diabetes
Jamilian M, Samimi M, Mirhosseini N, Afshar Ebrahimi F, Aghadavod E, Taghizadeh M, Asemi Z
Nutrients · 47 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-01-31 · Nutrients · vol. 10 · issue 2 · p. 163
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 56 citations · more than 98% of similar papers · 8.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Birth, Development, and Health · Gestational Diabetes Research and Management · Fatty Acid Research and Health
- Keywords
- Gestational diabetes, Fish oil, Internal medicine, Insulin resistance, Endocrinology, Docosahexaenoic acid, Medicine, Diabetes mellitus, Eicosapentaenoic acid, Dyslipidemia, Blood lipids, Pregnancy, Biology, Polyunsaturated fatty acid, Cholesterol, Fatty acid, Gestation
- MeSH
- humans, diabetes, gestational, insulin, lipids, docosahexaenoic acids, eicosapentaenoic acid, tumor necrosis factor-alpha, receptors, ldl, ppar gamma, inflammation mediators, interleukin-1, capsules, treatment outcome, administration, oral, double-blind method, gene expression regulation, pregnancy, time factors, dietary supplements, adult, iran, female, biomarkers
7 authors
From IR, CA
- Mehri JamilianArak University of Medical Sciences
- Mansooreh SamimiKashan University of Medical Sciences
- Naghmeh Zahra MirhosseiniPure North
- Faraneh Afshar EbrahimiKashan University of Medical Sciences
- Esmat AghadavodKashan University of Medical Sciences
- Mohsen TaghizadehKashan University of Medical Sciences
Abstract
Gestational diabetes mellitus (GDM) is a common complication of pregnancy, and it is mostly associated with postpartum diabetes, insulin resistance, and dyslipidemia. Fish oil (omega-3) supplementation has been shown to reduce the risk of different chronic diseases such as cardiovascular disease, type 2 diabetes, and cancers, though the evidence of its impact on gestational diabetes is scarce. Our goal in this study was to determine the effect of fish oil administration on gene expression related to insulin action, blood lipids, and inflammation in women with GDM. Participants with GDM (n = 40), aged 18-40 years, were randomized to take either 1000 mg fish oil capsules, containing 180 mg eicosapentaenoic acid and 120 mg docosahexaenoic acid (n = 20), or placebo (n = 20) twice a day for 6 weeks. Gene expression related to insulin, lipids, and inflammation was quantified in peripheral blood mononuclear cells (PBMCs) of GDM women using Reverse Transcription Polymerase Chain Reaction (RT-PCR) method. Results of RT-PCR indicated that omega-3 supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-γ) (P = 0.04) in PBMCs of patients with GDM, compared with the placebo. In addition, gene expression of the low-density lipoprotein receptor (LDLR) (P P = 0.007), and tumor necrosis factor alpha (TNF-α) (P = 0.01) was downregulated in PBMCs of women with GDM, following omega-3 supplementation. No significant effect of omega-3 supplementation was indicated on gene expression of IL-8 in PBMCs of patients with GDM. Overall, fish oil supplementation for 6 weeks in women with GDM significantly improved gene expression of PPAR-γ, IL-1, and TNF-α, but not gene expression of IL-8.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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