ACUTE EFFECT OF CAFFEINE ON MACULAR MICROCIRCULATION IN HEALTHY SUBJECTS: An Optical Coherence Tomography Angiography Study
Karti O, Zengin MO, Kerci SG, Ayhan Z, Kusbeci T
Retina (Philadelphia, Pa.) · 29 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-02-04 · Retina · vol. 39 · issue 5 · pp. 964–971
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 36 citations · more than 88% of similar papers · 2.4× the field average
- References
- 41 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Retinal Diseases and Treatments · Drug-Induced Ocular Toxicity
- Keywords
- Medicine, Caffeine, Placebo, Optical coherence tomography angiography, Foveal avascular zone, Ophthalmology, Macular degeneration, Optical coherence tomography, Internal medicine
- MeSH
- microcirculation, retinal vessels, fundus oculi, macula lutea, humans, caffeine, phosphodiesterase inhibitors, tomography, optical coherence, fluorescein angiography, administration, oral, dose-response relationship, drug, adult, middle aged, female, male, young adult, healthy volunteers
5 authors
From TR
- Ömer Kartı · correspondingIzmir Kâtip Çelebi University
- Mehmet Özgür Zengin · correspondingIzmir Kâtip Çelebi University
- Süleyman Gökhan Kerci · correspondingIzmir Kâtip Çelebi University
- Zi̇ya AyhanDokuz Eylül University
- Tuncay Küsbeci · correspondingIzmir Kâtip Çelebi University
Abstract
Purpose
To evaluate the acute effects of caffeine on macular microvasculature using quantitative optical coherence tomography angiography analysis.
Methods
Fifty-two healthy subjects aged 24 to 48 years were randomly divided into 2 groups: a control group, which received placebo, and a study group, which was subjected to caffeine. All participants underwent optical coherence tomography angiography at baseline and 1 hour after 200-mg oral caffeine intake in the study group and after oral placebo in the control group. Macular flow area, macular vessel density, and foveal avascular zone (FAZ) area were analyzed in both the groups.
Results
The study group consisted of 14 men and 12 women with a mean age of 40.6 ± 8.9 years. The mean age of control group was 39.5 ± 9.4 years, which consisted of 13 men and 13 women. Baseline macular flow area, vessel density, and FAZ area measurements of the study and control groups showed no significant difference (P > 0.05). Oral caffeine intake caused a significant reduction in macular flow area (superficial, deep, and choriocapillaris) and vessel density (P < 0.05). However, there was no statistically significant difference in FAZ area after caffeine intake when compared with baseline measurements (P = 0.063).
Conclusion
We found a significant decrease in macular flow area (superficial, deep, and choriocapillaris) and vessel density after caffeine intake. Our findings are consistent with previous studies using other techniques. We believe that the results of this preliminary study will be useful in future studies about this topic.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.