Intermittent fasting in Type 2 diabetes mellitus and the risk of hypoglycaemia: a randomized controlled trial
Corley BT, Carroll RW, Hall RM, Weatherall M, Parry-Strong A, Krebs JD
Diabetic medicine : a journal of the British Diabetic Association · 134 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Nonprofit
- New Zealand Society for the Study of Diabetes
Based on 1 listed funder(s).
Publication
- Published
- 2018-02-06 · Diabet Med · vol. 35 · issue 5 · pp. 588–594
- Publisher
- Wiley
- Cited
- 219 citations · more than 99% of similar papers · 9.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 21 works
- Access
- Paywalled
- Research areas
- Dietary Effects on Health · Diet and metabolism studies · Diabetes Management and Research
- Keywords
- Medicine, Internal medicine, Diabetes mellitus, Randomized controlled trial, Type 2 diabetes, Hypoglycemia, Weight loss, Intermittent fasting, Metformin, Calorie, Gastroenterology, Endocrinology, Obesity
- MeSH
- humans, diabetes mellitus, type 2, hypoglycemia, obesity, body weight, blood glucose, hypoglycemic agents, caloric restriction, fasting, quality of life, adult, aged, middle aged, female, male, glycated hemoglobin
6 authors
From NZ
- Brian Corley · correspondingWellington Hospital; University of Otago
- Richard W. CarrollWellington Hospital; University of Otago
- Rosemary M. HallWellington Hospital; University of Otago
- Mark W WeatherallUniversity of Otago
- Amber Parry‐StrongWellington Hospital
- Jeremy KrebsWellington Hospital; University of Otago
Abstract
Aims
To establish whether the risk of hypoglycaemia is greater with 2 consecutive days of very-low-calorie diet compared with 2 non-consecutive days of very-low-calorie diet in people with Type 2 diabetes.
Methods
This was a non-blinded randomized parallel group interventional trial of intermittent fasting in adults. The participants had a BMI of 30-45 kg/m2 , Type 2 diabetes treated with metformin and/or hypoglycaemic medications and an HbA1c concentration of 50-86 mmol/mol (6.7-10%). The participants followed a 2092-2510-kJ diet on 2 days per week for 12 weeks. A total of 41 participants were randomized 1:1 to consecutive (n=19) or non-consecutive (n=22) day fasts, of whom 37 (n=18 and n=19, respectively) were included in the final analysis. The primary outcome was difference in the rate of hypoglycaemia between the two study arms. Secondary outcomes included change in diet, quality of life, weight, lipid, glucose and HbA1c levels, and liver function.
Results
The mean hypoglycaemia rate was 1.4 events over 12 weeks. Fasting increased the rate of hypoglycaemia despite medication reduction (RR 2.05, 95% CI 1.17 to 3.52). There was no difference between fasting on consecutive days and fasting on non-consecutive days (RR 1.54, 95% CI 0.35 to 6.11). Improvements in weight, HbA1c , fasting glucose and quality of life were experienced by participants in both arms.
Conclusions
In individuals with Type 2 diabetes on hypoglycaemic medications, fasting of any type increased the rate of hypoglycaemia. With education and medication reduction, fewer than expected hypoglycaemic events occurred. Although it was not possible to determine whether fasting on consecutive days increased the risk of hypoglycaemia, an acceptable rate was observed in both arms.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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