Music Intervention Leads to Increased Insular Connectivity and Improved Clinical Symptoms in Schizophrenia
He H, Yang M, Duan M, Chen X, Lai Y, Xia Y, Shao J, Biswal BB, Luo C, Yao D
Frontiers in neuroscience · 38 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Chengdu Science and Technology Bureau
- Government
- Health and Family Planning Commission of Sichuan Province
- Grants
- National Natural Science Foundation of China (ZYGX2015J091); National Natural Science Foundation of China (16PJ051); National Natural Science Foundation of China (2013YQ490859); Chengdu Science and Technology Bureau (2013-11); National Natural Science Foundation of China (81330032); National Natural Science Foundation of China (B12027); National Natural Science Foundation of China (2013-11); National Natural Science Foundation of China (81471638); National Natural Science Foundation of China (2017JY0094)
Based on 3 listed funder(s).
Publication
- Published
- 2018-01-23 · Front Neurosci · vol. 11 · p. 744
- Publisher
- Frontiers Media
- Cited
- 104 citations · more than 99% of similar papers · 9.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 88 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Functional Brain Connectivity Studies · Neuroscience and Music Perception · Music Therapy and Health
- Keywords
- Schizophrenia (object-oriented programming), Intervention (counseling), Music therapy, Psychology, Antipsychotic, Insula, Functional magnetic resonance imaging, Medicine, Psychiatry, Neuroscience
10 authors
From CN
- Hui HeUniversity of Electronic Science and Technology of China
- Mi YangUniversity of Electronic Science and Technology of China
- Mingjun DuanUniversity of Electronic Science and Technology of China
- Xi ChenUniversity of Electronic Science and Technology of China
- Yongxiu LaiUniversity of Electronic Science and Technology of China
- Yang XiaUniversity of Electronic Science and Technology of China
Abstract
Schizophrenia is a syndrome that is typically accompanied by delusions and hallucinations that might be associated with insular pathology. Music intervention, as a complementary therapy, is commonly used to improve psychiatric symptoms in the maintenance stage of schizophrenia. In this study, we employed a longitudinal design to assess the effects of listening to Mozart music on the insular functional connectivity (FC) in patients with schizophrenia. Thirty-six schizophrenia patients were randomly divided into two equal groups as follows: the music intervention (MTSZ) group, which received a 1-month music intervention series combined with antipsychotic drugs, and the no-music intervention (UMTSZ) group, which was treated solely with antipsychotic drugs. Resting-state functional magnetic resonance imaging (fMRI) scans were performed at the following three timepoints: baseline, 1 month after baseline and 6 months after baseline. Nineteen healthy participants were recruited as controls. An FC analysis seeded in the insular subregions and machine learning techniques were used to examine intervention-related changes. After 1 month of listening to Mozart music, the MTSZ showed increased FC in the dorsal anterior insula (dAI) and posterior insular (PI) networks, including the dAI-ACC, PI-pre/postcentral cortices, and PI-ACC connectivity. However, these enhanced FCs had vanished in follow-up visits after 6 months. Additionally, a support vector regression on the FC of the dAI-ACC at baseline yielded a significant prediction of relative symptom remission in response to music intervention. Furthermore, the validation analyses revealed that 1 month of music intervention could facilitate improvement of the insular FC in schizophrenia. Together, these findings revealed that the insular cortex could potentially be an important region in music intervention for patients with schizophrenia, thus improving the patients' psychiatric symptoms through normalizing the salience and sensorimotor networks.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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