Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis
Langer-Gould A, Lucas RM, Xiang AH, Wu J, Chen LH, Gonzales E, Haraszti S, Smith JB, Quach H, Barcellos LF
Nutrients · 24 citations
How it was studied
- Design
- Case-control study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- NINDS NIH HHS
- Government
- National Institues of Health
- Grants
- National Institute of Neurological Disorders and Stroke (R01NS075308)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-02-07 · Nutrients · vol. 10 · issue 2 · p. 184
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 36 citations · more than 94% of similar papers · 3.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Multiple Sclerosis Research Studies · Psoriasis: Treatment and Pathogenesis
- Keywords
- Vitamin D and neurology, Vitamin D-binding protein, Multiple sclerosis, Allele, Medicine, Genotype, vitamin D deficiency, Haplotype, Internal medicine, Lower risk, Sun exposure, Calcitriol receptor, Endocrinology, Demography, Immunology, Genetics, Gene, Biology, Confidence interval
- MeSH
- humans, multiple sclerosis, vitamin d, vitamin d-binding protein, risk factors, sunlight, genotype, polymorphism, genetic, adult, middle aged, female, male, hispanic or latino, white people, black or african american
10 authors
From US, AU
- Annette Magdalene Langer-Gould · correspondingLos Angeles Medical Center
- Robyn Marjorie LucasAustralian National University
- Anny H. XiangKaiser Permanente
- Jun WuKaiser Permanente
- Lie ChenKaiser Permanente
- Edlin G. GonzalesKaiser Permanente
Abstract
Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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