Dietary Cholesterol Intake and Risk of Lung Cancer: A Meta-Analysis
Lin X, Liu L, Fu Y, Gao J, He Y, Wu Y, Lian X
Nutrients · 30 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- the National Natural Science Foundation of China
- Government
- the Natural Science Foundation of Chongqing Yuzhong District
- Grants
- National Natural Science Foundation of China (No.81071907)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-02-08 · Nutrients · vol. 10 · issue 2 · p. 185
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 39 citations · more than 57% of similar papers · 0.5× the field average
- References
- 33 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cancer, Lipids, and Metabolism · Nutritional Studies and Diet · Metabolomics and Mass Spectrometry Studies
- Keywords
- Meta-analysis, Lung cancer, Medicine, Cholesterol, Dietary Cholesterol, Internal medicine, Oncology, Risk factor, Environmental health
- MeSH
- animals, humans, lung neoplasms, cholesterol, dietary, diet, fat-restricted, risk, reproducibility of results, diet, high-fat, diet, healthy
7 authors
From CN
- Xiaojing LinMinistry of Education of the People's Republic of China; Chongqing Public Health Medical Center; Chongqing Medical University
- Lingli LiuChongqing Public Health Medical Center; Chongqing Medical University
- Youyun FuMinistry of Education of the People's Republic of China; Chongqing Public Health Medical Center; Chongqing Medical University
- Jing GaoChongqing Public Health Medical Center; Chongqing Medical University
- Yunyun HeChongqing Public Health Medical Center; Chongqing Medical University
- Yang WuChongqing Medical University
Abstract
Multiple epidemiologic studies have evaluated the relationship between dietary cholesterol and lung cancer risk, but the association is controversial and inconclusive. A meta-analysis of case-control studies and cohort studies was conducted to evaluate the relationship between dietary cholesterol intake and lung cancer risk in this study. A relevant literature search up to October 2017 was performed in Web of Science, PubMed, China National Knowledge Infrastructure, Sinomed, and VIP Journal Integration Platform. Ten case-control studies and six cohort studies were included in the meta-analysis, and the risk estimates were pooled using either fixed or random effects models. The case-control studies with a total of 6894 lung cancer cases and 29,736 controls showed that dietary cholesterol intake was positively associated with lung cancer risk (Odds Ratio = 1.70, 95% Confidence Interval: 1.43-2.03). However, there was no evidence of an association between dietary cholesterol intake and risk of lung cancer among the 241,920 participants and 1769 lung cancer cases in the cohort studies (Relative Risk = 1.08, 95% Confidence Interval: 0.94-1.25). Due to inconsistent results from case-control and cohort studies, it is difficult to draw any conclusion regarding the effects of dietary cholesterol intake on lung cancer risk. Carefully designed and well-conducted cohort studies are needed to identify the association between dietary cholesterol and lung cancer risk.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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