Caffeine Caused a Widespread Increase of Resting Brain Entropy
Chang D, Song D, Zhang J, Shang Y, Ge Q, Wang Z
Scientific reports · 51 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Natural Science Foundation of Zhejiang Province
- Grants
- National Natural Science Foundation of China (61671198); Natural Science Foundation of Zhejiang Province (Grant LZ15H180001); Natural Science Foundation of Zhejiang Province (LZ15H180001)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-02-05 · Sci Rep · vol. 8 · issue 1 · p. 2700
- Publisher
- Nature Portfolio
- Cited
- 70 citations · more than 90% of similar papers · 2.6× the field average
- References
- 45 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Diet and metabolism studies · Neurological disorders and treatments · Neurological and metabolic disorders
- Keywords
- Caffeine, Resting state fMRI, Medicine, Neuroscience, Internal medicine, Biology
- MeSH
- brain, cerebral cortex, visual cortex, humans, caffeine, magnetic resonance imaging, brain mapping, attention, wakefulness, cerebrovascular circulation, entropy, adult, china, female, male, young adult, healthy volunteers
6 authors
From CN, US
- Da Wei ChangHangzhou Normal University
- Donghui SongHangzhou Normal University
- Jian ZhangHangzhou Normal University
- Yuanqi ShangHangzhou Normal University
- Qiu GeHangzhou Normal University
- Ze Wang · correspondingHangzhou Normal University; Temple University
Abstract
Entropy is an important trait of brain function and high entropy indicates high information processing capacity. We recently demonstrated that brain entropy (BEN) is stable across time and differs between controls and patients with various brain disorders. The purpose of this study was to examine whether BEN is sensitive to pharmaceutical modulations with caffeine. Both cerebral blood flow (CBF) and resting fMRI were collected from sixty caffeine-naïve healthy subjects before and after taking a 200 mg caffeine pill. Our data showed that caffeine reduced CBF in the whole brain but increased BEN across the cerebral cortex with the highest increase in lateral prefrontal cortex, the default mode network (DMN), visual cortex, and motor network, consistent with the beneficial effects of caffeine (such as vigilance and attention) on these areas. BEN increase was correlated to CBF reduction only in several regions (-0.5 < r < -0.4), indicating a neuronal nature for most of the observed BEN alterations. In summary, we showed the first evidence of BEN alterations due to caffeine ingestion, suggesting BEN as a biomarker sensitive to pharmaceutical brain function modulations.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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