Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort
Fiolet T, Srour B, Sellem L, Kesse-Guyot E, Allès B, Méjean C, Deschasaux M, Fassier P, Latino-Martel P, Beslay M, Hercberg S, Lavalette C, Monteiro CA, Julia C, Touvier M
BMJ (Clinical research ed.) · 629 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Independent funding
- Government
- Ministère de la Santé
Based on 1 listed funder(s).
Publication
- Published
- 2018-02-14 · BMJ · vol. 360 · p. k322
- Cited
- 1034 citations · more than 100% of similar papers · 90.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (hybrid journal) · CC-BY-NC
- Research areas
- Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease · Food composition and properties
- Keywords
- Medicine, Hazard ratio, Prospective cohort study, Breast cancer, Confidence interval, Cohort study, Population, Relative risk, Cohort, Cancer, Proportional hazards model, Environmental health, Internal medicine
- MeSH
- humans, neoplasms, diet, risk factors, prospective studies, food handling, adult, france, female, male, fast foods
15 authors
From FR, BR
- Thibault FioletInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Bernard SrourInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Laury SellemInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Emmanuelle Kesse‐GuyotInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Benjamin AllèsInserm; Université Paris Cité; Université Sorbonne Paris Nord; Sorbonne Paris Cité; Equipe de Recherche en Epidémiologie Nutritionnelle; Centre de Recherche Épidémiologie et Statistique
- Caroline MéjeanInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement; Montpellier Interdisciplinary center on Sustainable Agri-food systems: social and nutritional sciences
Abstract
Objective
To assess the prospective associations between consumption of ultra-processed food and risk of cancer.
Design
Population based cohort study.
Setting and participants
104 980 participants aged at least 18 years (median age 42.8 years) from the French NutriNet-Santé cohort (2009-17). Dietary intakes were collected using repeated 24 hour dietary records, designed to register participants' usual consumption for 3300 different food items. These were categorised according to their degree of processing by the NOVA classification.
Main outcome measures
Associations between ultra-processed food intake and risk of overall, breast, prostate, and colorectal cancer assessed by multivariable Cox proportional hazard models adjusted for known risk factors.
Results
Ultra-processed food intake was associated with higher overall cancer risk (n=2228 cases; hazard ratio for a 10% increment in the proportion of ultra-processed food in the diet 1.12 (95% confidence interval 1.06 to 1.18); P for trend<0.001) and breast cancer risk (n=739 cases; hazard ratio 1.11 (1.02 to 1.22); P for trend=0.02). These results remained statistically significant after adjustment for several markers of the nutritional quality of the diet (lipid, sodium, and carbohydrate intakes and/or a Western pattern derived by principal component analysis).
Conclusions
In this large prospective study, a 10% increase in the proportion of ultra-processed foods in the diet was associated with a significant increase of greater than 10% in risks of overall and breast cancer. Further studies are needed to better understand the relative effect of the various dimensions of processing (nutritional composition, food additives, contact materials, and neoformed contaminants) in these associations.
Study registration
Clinicaltrials.gov NCT03335644.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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