Green leafy and cruciferous vegetable consumption and risk of type 2 diabetes: results from the Singapore Chinese Health Study and meta-analysis
Chen GC, Koh WP, Yuan JM, Qin LQ, van Dam RM
The British journal of nutrition · 42 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- University or hospital
- National University of Singapore
- Government
- China Scholarship Council
- Government
- National Institutes of Health
- Government
- Medical Research Council
- Government
- National Medical Research Council
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- Grants
- Medical Research Council (NMRC/CSA/0055/2013); National Cancer Institute (R01CA144034); National Institutes of Health (NIH-R01); National Medical Research Council (NMRC/CSA/0055/2013); National Cancer Institute (UM1 CA182876); National Institutes of Health (UM1CA182876); National Institutes of Health (CA182876); National Institutes of Health (R01-CA144034); National Institutes of Health (NIH R01 CA144034); National Institutes of Health (R01 CA144034 and UM1 CA182876); National Institutes of Health (CA144034)
Based on 7 listed funder(s).
Publication
- Published
- 2018-02-19 · Br J Nutr · vol. 119 · issue 9 · pp. 1057–1067
- Publisher
- Cambridge University Press
- Cited
- 55 citations · more than 92% of similar papers · 3.5× the field average
- Impact
- Top 10% most cited in its field
- References
- 52 works
- Access
- Free to read
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Diet and metabolism studies
- Keywords
- Cruciferous vegetables, Medicine, Hazard ratio, Type 2 diabetes, Environmental health, Lower risk, Confounding, Prospective cohort study, Proportional hazards model, Relative risk, Population, Demography, Diabetes mellitus, Confidence interval, Internal medicine, Endocrinology, Cancer
- MeSH
- humans, brassicaceae, vegetables, diabetes mellitus, type 2, diet, risk factors, feeding behavior, aged, middle aged, singapore, female, male, asian people
5 authors
From SG, CN, US
- Guo‐Chong ChenNational University of Singapore; Soochow University
- Woon‐Puay KohNational University of Singapore; Duke-NUS Medical School; National University Health System
- Jian‐Min YuanUniversity of Pittsburgh; UPMC Hillman Cancer Center
- Li‐Qiang QinSoochow University
- Rob M. van Dam · correspondingNational University of Singapore; National University Health System
Abstract
Several previous prospective studies suggest that consumption of green leafy and cruciferous vegetables may lower the risk of type 2 diabetes (T2D). We investigated the association between consumption of different types of vegetables in relation to T2D risk in an Asian Population. We included 45 411 participants (age range: 45-74 years) of the Singapore Chinese Health Study (SCHS) free of diabetes, cancer or CVD at baseline (1993-1998). Dietary information was collected using a validated FFQ. Physician-diagnosed incident diabetes was reported at follow-up I (1999-2004) and II (2006-2010) interviews. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95 % CI of T2D risk. An updated meta-analysis was also conducted to summarise results for green leafy and cruciferous vegetables. During 494 741 person-years of follow-up, 5207 incident T2D occurred. After adjustment for potential confounders, neither total vegetables (top v. bottom quintile HR=1·08; 95 % CI 0·98, 1·18, P trend=0·66) nor specific vegetables including dark green leafy vegetables (HR=1·05; 95 % CI 0·96, 1·15, P trend=0·21) and cruciferous vegetables (HR=0·97; 95 % CI 0·88, 1·06, P trend=0·29) were substantially associated with risk of T2D. A meta-analysis (eleven studies with 754 729 participants and 58 297 cases) including the SCHS and all previous prospective studies suggested borderline significant inverse associations between green leafy (summary relative risk (RR)=0·91; 95 % CI 0·84, 1·00) and cruciferous vegetable consumption (RR=0·87; 95 % CI 0·76, 1·00) and T2D risk, with moderate-to-high heterogeneity. In conclusion, green leafy or cruciferous vegetable consumption was not substantially associated with risk of T2D in an Asian population. Meta-analysis of available cohort data indicated that evidence for a beneficial effect of green leafy or cruciferous vegetable consumption on T2D risk is not convincing.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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