Divergent effects of cold water immersion versus active recovery on skeletal muscle fiber type and angiogenesis in young men
D'Souza RF, Zeng N, Markworth JF, Figueiredo VC, Roberts LA, Raastad T, Coombes JS, Peake JM, Cameron-Smith D, Mitchell CJ
American journal of physiology. Regulatory, integrative and comparative physiology · 18 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Possibly industry funded
- Industry group
- AgResearch
- University or hospital
- Queensland University of Technology
- University or hospital
- International Postgraduate Research Scholarship, University of Queensland
- Nonprofit
- American College of Sports Medicine Research Foundation
- University or hospital
- Queensland University of Technology (QUT)
- Company
- AgResearch (AgResearch Limited)
- Industry group
- Exercise and Sport Science Australia
Based on 7 listed funder(s).
Publication
- Published
- 2018-02-21 · Am J Physiol Regul Integr Comp Physiol · vol. 314 · issue 6 · pp. R824–R833
- Publisher
- American Physiological Society
- Cited
- 22 citations · more than 88% of similar papers · 2.3× the field average
- References
- 60 works
- Access
- Paywalled
- Research areas
- Exercise and Physiological Responses · Spaceflight effects on biology · Thermoregulation and physiological responses
- Keywords
- Angiogenesis, Fiber type, Immersion (mathematics), Skeletal muscle, Muscle fibre, Fiber, Chemistry, Internal medicine, Medicine, Materials science, Composite material
- MeSH
- muscle, skeletal, capillaries, humans, cardiac myosins, vascular endothelial growth factor a, myosin heavy chains, micrornas, immersion, regional blood flow, neovascularization, physiologic, male, muscle strength, cold temperature, muscle fibers, skeletal, resistance training, young adult
10 authors
From NZ, US, AU, NO
- Randall F. D’SouzaUniversity of Auckland
- Nina ZengUniversity of Auckland
- James F. MarkworthUniversity of Auckland
- Vandré C. FigueiredoUniversity of Kentucky; University of Auckland
- Llion Arwyn RobertsGriffith University; The University of Queensland; Queensland Academy of Sport
- Truls RaastadNorwegian School of Sport Sciences
Abstract
Resistance training (RT) increases muscle fiber size and induces angiogenesis to maintain capillary density. Cold water immersion (CWI), a common postexercise recovery modality, may improve acute recovery, but it attenuates muscle hypertrophy compared with active recovery (ACT). It is unknown if CWI following RT alters muscle fiber type expression or angiogenesis. Twenty-one men strength trained for 12 wk, with either 10 min of CWI ( n = 11) or ACT ( n = 10) performed following each session. Vastus lateralis biopsies were collected at rest before and after training. Type IIx myofiber percent decreased ( P = 0.013) and type IIa myofiber percent increased with training ( P = 0.012), with no difference between groups. The number of capillaries per fiber increased from pretraining in the CWI group ( P = 0.004) but not the ACT group ( P = 0.955). Expression of myosin heavy chain genes ( MYH1 and MYH2), encoding type IIx and IIa fibers, respectively, decreased in the ACT group, whereas MYH7 (encoding type I fibers) increased in the ACT group versus CWI ( P = 0.004). Myosin heavy chain IIa protein increased with training ( P = 0.012) with no difference between groups. The proangiogenic vascular endothelial growth factor protein decreased posttraining in the ACT group versus CWI ( P < 0.001), whereas antiangiogenic Sprouty-related, EVH1 domain-containing protein 1 protein increased with training in both groups ( P = 0.015). Expression of microRNAs that regulate muscle fiber type (miR-208b and -499a) and angiogenesis (miR-15a, -16, and -126) increased only in the ACT group ( P < 0.05). CWI recovery after each training session altered the angiogenic and fiber type-specific response to RT through regulation at the levels of microRNA, gene, and protein expression.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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