Whole-Body Cryotherapy Decreases the Levels of Inflammatory, Oxidative Stress, and Atherosclerosis Plaque Markers in Male Patients with Active-Phase Ankylosing Spondylitis in the Absence of Classical Cardiovascular Risk Factors
Stanek A, Cholewka A, Wielkoszyński T, Romuk E, Sieroń A
Mediators of inflammation · 35 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Śląski Uniwersytet Medyczny
- University or hospital
- Uniwersytet Śląski w Katowicach
- Grants
- Śląski Uniwersytet Medyczny (KNW-640-2-1-376/17); Śląski Uniwersytet Medyczny (KNW-1-045/K/7/K)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Mediators Inflamm · vol. 2018 · pp. 1–11
- Publisher
- Hindawi Publishing Corporation
- Cited
- 55 citations · more than 95% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Spondyloarthritis Studies and Treatments · Exercise and Physiological Responses · Inflammatory Myopathies and Dermatomyositis
- Keywords
- BASFI, Ankylosing spondylitis, BASDAI, Medicine, Oxidative stress, Internal medicine, Spondylitis, Antioxidant, Gastroenterology, Lipid profile, Inflammation, Endocrinology, Immunology, Cholesterol, Disease, Biology, Biochemistry
- MeSH
- humans, spondylitis, ankylosing, cardiovascular diseases, treatment outcome, cryotherapy, risk factors, oxidative stress, adult, middle aged, male, plaque, atherosclerotic, biomarkers
5 authors
From PL
- Agata Stanek · correspondingMedical University of Silesia
- Armand CholewkaInstitute of Physics; University of Silesia in Katowice
- Tomasz WielkoszyńskiMedical University of Silesia
- Ewa Barbara RomukMedical University of Silesia
- Aleksander SierońMedical University of Silesia
Abstract
Objective
The aim of the study was to estimate the impact of whole-body cryotherapy (WBC) on cardiovascular risk factors in patients with ankylosing spondylitis (AS).
Material and methods
We investigated the effect of WBC with subsequent kinesiotherapy on markers of inflammation, oxidative stress, lipid profile, and atherosclerosis plaque in male AS patients (WBC group). To assess the disease activity, the BASDAI and BASFI were also calculated. The results from the WBC group were compared with results from the kinesiotherapy (KT) group.
Results
The results showed that in the WBC group, the plasma hsCRP level decreased without change to the IL-6 level. The ICAM-1 level showed a decreasing tendency. The CER concentration, as well as the BASDAI and BASFI, decreased in both groups, but the index changes of disease activity were higher in the WBC than KT patients. Additionally, in the WBC group, we observed a decrease in oxidative stress markers, changes in the activity of some antioxidant enzymes and nonenzymatic antioxidant parameters. In both groups, the total cholesterol and LDL cholesterol, triglycerides, sCD40L, PAPP-A, and PLGF levels decreased, but the parameter changes were higher in the WBC group.
Conclusion
WBC appears to be a useful method of atherosclerosis prevention in AS patients.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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