In Vivo Evaluation of Withania somnifera-Based Indian Traditional Formulation ( Amukkara Choornam), Against Chikungunya Virus-Induced Morbidity and Arthralgia
Jain J, Narayanan V, Chaturvedi S, Pai S, Sunil S
Journal of evidence-based integrative medicine · 19 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Ministry of AYUSH, Government of India
- University or hospital
- International Centre for Genetic Engineering and Biotechnology
- Grants
- Ministry of AYUSH, Government of India (ND/AYU/15/019)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · J Evid Based Integr Med · vol. 23 · p. 2156587218757661
- Publisher
- SAGE Publishing
- Cited
- 37 citations · more than 93% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 31 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Mosquito-borne diseases and control · Phytochemicals and Medicinal Plants
- Keywords
- Chikungunya, Medicine, Chikungunya fever, Alphavirus, Sindbis virus, Virus, In vivo, Immunology, Virology, Biology
- MeSH
- animals, mice, inbred c57bl, humans, mice, chikungunya virus, withania, arthralgia, plant extracts, medicine, traditional, viral load, morbidity, drug evaluation, preclinical, india, female, male, chikungunya fever
5 authors
From IN
- Jaspreet JainInternational Centre for Genetic Engineering and Biotechnology
- Vimal NarayananInternational Centre for Genetic Engineering and Biotechnology
- Shivam ChaturvediInternational Centre for Genetic Engineering and Biotechnology
- Somnath S. PaiAmity University
- Sujatha Sunil · correspondingInternational Centre for Genetic Engineering and Biotechnology
Abstract
Chikungunya viral fever results in extreme morbidity and arthralgia in affected individuals. Currently, modern medicines providing symptomatic relief for the acute febrile phase and the chronic arthritic phase are only options available. Traditional Indian medical system, however, uses specific formulations for treatment of this infection; one such polyherbal formulation used to treat the postpyretic phase of chikungunya is amukkara choornam. The current study was undertaken to study the efficacy of amukkara choornam in the treatment of chikungunya in C57BL/6J mice. The formulation when administered to chikungunya-infected mice relieved morbidity and joint swelling. Analysis of virus clearance in brain and joint tissues on formulation treatment revealed a direct correlation of viral load in brain to morbidity during infection; likewise, joint swelling receded prior to complete viral clearance explaining possible immunomodulatory effect of amukkara choornam. This study provides insight into the possible mode of action of amukkara choornam during chikungunya.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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