Intake of 3 Eggs per Day When Compared to a Choline Bitartrate Supplement, Downregulates Cholesterol Synthesis without Changing the LDL/HDL Ratio
Lemos BS, Medina-Vera I, Blesso CN, Fernandez ML
Nutrients · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food diaries or recalls
Who paid for it
- Funding
- Industry funded
- Government
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Authors
- At least one author declares a financial tie to industry
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-02-24 · Nutrients · vol. 10 · issue 2 · p. 258
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 52 citations · more than 96% of similar papers · 5.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 53 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Cholesterol and Lipid Metabolism · Diet, Metabolism, and Disease · Nutritional Studies and Diet
- Keywords
- Choline, Cholesterol, Chemistry, Ldl cholesterol, Internal medicine, Endocrinology, Food science, Medicine, Biochemistry
- MeSH
- leukocytes, mononuclear, humans, choline, creatinine, cholesterol, hydroxymethylglutaryl coa reductases, blood glucose, cholesterol, dietary, triglycerides, apolipoproteins, body mass index, diet, cross-over studies, sample size, dietary supplements, eggs, adolescent, adult, diet records, female, male, lipid metabolism, sterol regulatory element binding protein 2, cholesterol, ldl, cholesterol, hdl, waist circumference, young adult
4 authors
From US, MX
- Bruno S. LemosUniversity of Connecticut
- Isabel VeraInstituto Nacional de Pediatria
- Christopher N. BlessoUniversity of Connecticut
- María Luz FernándezUniversity of Connecticut
Abstract
Cardiovascular disease (CVD) risk is associated with high concentrations of low-density lipoprotein cholesterol (LDL-C). The impact of dietary cholesterol on plasma lipid concentrations still remains a concern. The effects of egg intake in comparison to choline bitartrate supplement was studied in a young, healthy population. Thirty participants were enrolled for a 13-week intervention. After a 2-week run-in period, subjects were randomized to consume either 3 eggs/day or a choline bitartrate supplement (~400 mg choline for both treatments) for 4-weeks each. After a 3-week washout period, they were allocated to the alternate treatment. Dietary records, plasma lipids, apolipoproteins (apo) concentrations, and peripheral blood mononuclear cell expression of regulatory genes for cholesterol homeostasis were assessed at the end of each intervention. Dietary intakes of saturated and monounsaturated fat were higher with the consumption of eggs compared to the choline period. In addition, higher plasma concentrations of total cholesterol (7.5%), high density lipoprotein cholesterol (HDL-C) (5%) and LDL-C (8.1%) were observed with egg consumption (p p < 0.05), suggesting a compensation to the increased dietary cholesterol load. Therefore, dietary cholesterol from eggs appears to regulate endogenous synthesis of cholesterol in such a way that the LDL-C/HDL-C ratio is maintained.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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