Caffeine, CYP1A2 Genotype, and Endurance Performance in Athletes
Guest N, Corey P, Vescovi J, El-Sohemy A
Medicine and science in sports and exercise · 140 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- Canadian Institutes of Health Research
- Government
- CIHR
Based on 2 listed funder(s).
Publication
- Published
- 2018-03-06 · Med Sci Sports Exerc · vol. 50 · issue 8 · pp. 1570–1578
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 231 citations · more than 100% of similar papers · 15.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Muscle metabolism and nutrition · Exercise and Physiological Responses
- Keywords
- Caffeine, CYP1A2, Cycling, Time trial, Placebo, Genotype, Internal medicine, Athletes, Saliva, Animal science, Endocrinology, Medicine, Chemistry, Biology, Metabolism, Heart rate, Physical therapy, Biochemistry, Gene, Cytochrome P450, Blood pressure
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, exercise test, double-blind method, perception, heart rate, physical endurance, genotype, polymorphism, single nucleotide, adult, male, physical exertion, young adult
4 authors
From CA
- Nanci S. GuestUniversity of Toronto
- Paul CoreyUniversity of Toronto; Public Health Ontario
- Jason D. VescoviUniversity of Toronto
- Ahmed El‐SohemyUniversity of Toronto
Abstract
Purpose
Many studies have examined the effect of caffeine on exercise performance, but findings have not always been consistent. The objective of this study was to determine whether variation in the CYP1A2 gene, which affects caffeine metabolism, modifies the ergogenic effects of caffeine in a 10-km cycling time trial.
Methods
Competitive male athletes (n = 101; age = 25 ± 4 yr) completed the time trial under three conditions: 0, 2, or 4 mg of caffeine per kilogram body mass, using a split-plot randomized, double-blinded, placebo-controlled design. DNA was isolated from saliva and genotyped for the -163A > C polymorphism in the CYP1A2 gene (rs762551).
Results
Overall, 4 mg·kg caffeine decreased cycling time by 3% (mean ± SEM) versus placebo (17.6 ± 0.1 vs 18.1 ± 0.1 min, P = 0.01). However, a significant (P <0.0001) caffeine-gene interaction was observed. Among those with the AA genotype, cycling time decreased by 4.8% at 2 mg·kg (17.0 ± 0.3 vs 17.8 ± 0.4 min, P = 0.0005) and by 6.8% at 4 mg·kg (16.6 ± 0.3 vs 17.8 ± 0.4 min, P < 0.0001). In those with the CC genotype, 4 mg·kg increased cycling time by 13.7% versus placebo (20.8 ± 0.8 vs 18.3 ± 0.5 min, P = 0.04). No effects were observed among those with the AC genotype.
Conclusion
Our findings show that both 2 and 4 mg·kg caffeine improve 10-km cycling time, but only in those with the AA genotype. Caffeine had no effect in those with the AC genotype and diminished performance at 4 mg·kg in those with the CC genotype. CYP1A2 genotype should be considered when deciding whether an athlete should use caffeine for enhancing endurance performance.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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