Higher Dietary Magnesium Intake and Higher Magnesium Status Are Associated with Lower Prevalence of Coronary Heart Disease in Patients with Type 2 Diabetes
Gant CM, Soedamah-Muthu SS, Binnenmars SH, Bakker SJL, Navis G, Laverman GD
Nutrients · 20 citations
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-03-05 · Nutrients · vol. 10 · issue 3 · p. 307
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 25 citations · more than 85% of similar papers · 2.0× the field average
- References
- 43 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Magnesium in Health and Disease · Parathyroid Disorders and Treatments
- Keywords
- Magnesium, Medicine, Quartile, Internal medicine, Diabetes mellitus, Cohort, Magnesium deficiency (plants), Type 2 diabetes, Hazard ratio, Endocrinology, Cohort study, Excretion, Urinary system, Gastroenterology, Confidence interval, Chemistry
- MeSH
- humans, coronary disease, diabetes mellitus, type 2, magnesium deficiency, magnesium, diet, prevalence, risk factors, cross-sectional studies, nutritional status, aged, middle aged, netherlands, female, male, recommended dietary allowances, protective factors, biomarkers
6 authors
From NL, GB
- Christina Maria GantUniversity Medical Center Groningen; University of Groningen; Ziekenhuis Groep Twente
- Sabita S. Soedamah‐MuthuTilburg University; University of Reading
- S. Heleen BinnenmarsUniversity Medical Center Groningen; University of Groningen
- Stephan J. L. BakkerUniversity Medical Center Groningen; University of Groningen
- Gerjan J NavisUniversity Medical Center Groningen; University of Groningen
- Gozewijn Dirk Laverman · correspondingZiekenhuis Groep Twente
Abstract
In type 2 diabetes mellitus (T2D), the handling of magnesium is disturbed. Magnesium deficiency may be associated with a higher risk of coronary heart disease (CHD). We investigated the associations between (1) dietary magnesium intake; (2) 24 h urinary magnesium excretion; and (3) plasma magnesium concentration with prevalent CHD in T2D patients. This cross-sectional analysis was performed on baseline data from the DIAbetes and LifEstyle Cohort Twente-1 (DIALECT-1, n = 450, age 63 ± 9 years, 57% men, and diabetes duration of 11 (7-18) years). Prevalence ratios (95% CI) of CHD by sex-specific quartiles of magnesium indicators, as well as by magnesium intake per dietary source, were determined using multivariable Cox proportional hazard models. CHD was present in 100 (22%) subjects. Adjusted CHD prevalence ratios for the highest compared to the lowest quartiles were 0.40 (0.20, 0.79) for magnesium intake, 0.63 (0.32, 1.26) for 24 h urinary magnesium excretion, and 0.62 (0.32, 1.20) for plasma magnesium concentration. For every 10 mg increase of magnesium intake from vegetables, the prevalence of CHD was, statistically non-significantly, lower (0.75 (0.52, 1.08)). In this T2D cohort, higher magnesium intake, higher 24 h urinary magnesium excretion, and higher plasma magnesium concentration are associated with a lower prevalence of CHD.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.