Broccoli and human health: immunomodulatory effect of sulforaphane in a model of colon cancer
Bessler H, Djaldetti M
International journal of food sciences and nutrition · 30 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-03-07 · Int J Food Sci Nutr · vol. 69 · issue 8 · pp. 946–953
- Publisher
- Taylor & Francis
- Cited
- 49 citations · more than 83% of similar papers · 1.6× the field average
- References
- 41 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Immune Cell Function and Interaction · IL-33, ST2, and ILC Pathways
- Keywords
- Sulforaphane, Glucoraphanin, Immune system, Peripheral blood mononuclear cell, Cytokine, Colorectal cancer, Cancer cell, Chemistry, Cancer research, Cancer, Pharmacology, Immunology, Medicine, Biology, Internal medicine, Biochemistry, In vitro, Botany, Glucosinolate, Brassica
- MeSH
- leukocytes, mononuclear, cell line, tumor, ht29 cells, humans, brassica, colonic neoplasms, isothiocyanates, sulfoxides, anti-inflammatory agents, anticarcinogenic agents, cytokines, cell proliferation, cell survival
2 authors
From IL
- Hanna Bessler · correspondingTel Aviv University; Rabin Medical Center
- Meir DjaldettiTel Aviv University; Rabin Medical Center
Abstract
The favourable properties of broccoli on human health are due to their abundant content of vitamins, minerals and isothiocyanates, the sulforaphane (SFN) being the most important. SFN is created from its precursor glucoraphanin and it is released by myrosinase enzymes produced during crushing of the plant. SFN has been shown to possess anti-inflammatory and anticancer properties. The aim of the study was to determine if SFN may affect the immune dialogue between human peripheral blood mononuclear cells (PBMCs) and HT-29 and RKO human colon cancer cells lines. Non- or mitogen-stimulated PBMCs were incubated with various concentrations of SFN, and the secretion of TNFα, IL-1β, IL-6, IFNγ, IL-2, IL-10 and IL-1ra was determined. In addition, the effect of SFN on the production of these cytokines by PBMCs co-cultured with colon carcinoma cells was examined. SFN exerted a concentration-dependent inhibitory effect on the inflammatory cytokine production by the immune cells. The impact of SFN on the interaction between immune and colon cancer cells underscores its capacity for cancer prevention and development.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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