Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7-d, double-blind, randomised, placebo-controlled, cross-over trial
Kerley CP, Dolan E, James PE, Cormican L
The British journal of nutrition · 24 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Irish Heart Foundation
Based on 1 listed funder(s).
Publication
- Published
- 2018-03-19 · Br J Nutr · vol. 119 · issue 6 · pp. 658–663
- Publisher
- Cambridge University Press
- Cited
- 37 citations · more than 89% of similar papers · 2.5× the field average
- References
- 41 works
- Access
- Free to read
- Research areas
- Nitric Oxide and Endothelin Effects · Blood Pressure and Hypertension Studies · Sodium Intake and Health
- Keywords
- Blood pressure, Placebo, Medicine, Ambulatory, Ambulatory blood pressure, Double blind, Internal medicine, Randomized controlled trial, Nitrate, Cardiology, Chemistry
- MeSH
- humans, hypertension, obesity, nitrates, nitrites, bilirubin, cholesterol, alkaline phosphatase, alanine transaminase, triglycerides, c-reactive protein, antihypertensive agents, blood pressure monitoring, ambulatory, body mass index, treatment outcome, cross-over studies, double-blind method, life style, blood pressure, aged, middle aged, female, male
4 authors
From IE, GB
- Conor P. Kerley · correspondingConnolly Hospital Blanchardstown
- Eamon DolanConnolly Hospital Blanchardstown
- Philip E. JamesCardiff Metropolitan University
- Liam J. CormicanConnolly Hospital Blanchardstown
Abstract
Dietary nitrate has been shown to increase nitrate/nitrite levels and decrease blood pressure (BP) in multiple populations. There are few reports among hypertensives and these reports have provided conflicting evidence. We aimed to assess the effect of daily nitrate compared with placebo in subjects with uncontrolled hypertension (HTN). On day 0, hypertensives wore an ambulatory BP monitor (ABPM) for 24 h and blood was taken. Subjects were then randomised to 7-d nitrate-rich beetroot juice (NO3 -) (12·9 mmol nitrate) followed by 7-d nitrate-depleted beetroot juice (0·5 mmol nitrate) or vice versa. ABPM and blood were assessed before and after both conditions. In all, twenty subjects with treated yet uncontrolled HTN entered and completed the trial (mean age=62·5 years, mean BMI=30·7 kg/m2). Baseline BP was 137/80 (sd 7/7) mmHg. Dietary nitrate was well tolerated and resulted in significantly increased plasma nitrite (P=0·0004) and decreased 24-h systolic BP and diastolic BP compared with placebo (-8 mmHg; P=0·012 and -4 mmHg; P=0·018, respectively). Our results support the existing data suggesting an anti-hypertensive effect of dietary nitrate in treated yet uncontrolled hypertensives. Targeted dietary strategies appear promising contributors to BP control.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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