Processed Meat and Risk of Renal Cell and Bladder Cancers
Rosato V, Negri E, Serraino D, Montella M, Libra M, Lagiou P, Facchini G, Ferraroni M, Decarli A, La Vecchia C
Nutrition and cancer · 6 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Associazione Italiana per la Ricerca sul Cancro
Based on 1 listed funder(s).
Publication
- Published
- 2018-03-23 · Nutr Cancer · vol. 70 · issue 3 · pp. 418–424
- Publisher
- Routledge
- Cited
- 9 citations · more than 72% of similar papers · 0.7× the field average
- References
- 35 works
- Access
- Paywalled
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Nutrition, Genetics, and Disease
- Keywords
- Medicine, Urology, Bladder cancer, Internal medicine, Oncology, Cancer
- MeSH
- humans, carcinoma, renal cell, kidney neoplasms, odds ratio, risk factors, case-control studies, eating, food handling, meat products, adult, aged, middle aged, italy, female, male, urinary bladder neoplasms
10 authors
From IT, US, GR
- Valentina Rosato
- Eva NegriUniversity of Milan
- Diego SerrainoCentro di Riferimento Oncologico
- Maurizio MontellaIstituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
- Massimo LibraUniversity of Catania
- Pagona LagiouHarvard University; National and Kapodistrian University of Athens
Abstract
We assessed the association of processed meat intake with the risk of renal cell carcinoma (RCC) and bladder cancer. We used data from two Italian hospital-based case-control studies, including 1,115 RCC cases and 2,582 controls, and 1,417 bladder cancer cases and 1,732 controls. We calculated odds ratios (ORs) and 95% confidence intervals (CIs) with unconditional logistic regression models, adjusted for major confounders. The median consumption of processed meat in cases and controls was around 2 portions/week (50 g/portion). The ORs for a daily 10 g increment of processed meat was 0.89 (95% CI 0.84-0.94) for RCC and 1.00 (95% CI 0.94-1.06) for bladder cancer. The OR for the highest vs. the lowest consumption was 0.80 (95% CI 0.66-0.96) for RCC and 0.98 (95% CI 0.80-1.21) for bladder cancer. The ORs were consistent in strata of various covariates. For bladder cancer, however, a significant 23% excess risk was found in women (95% CI 1.03-1.47) for a daily increase of 10 g, significantly heterogeneous from the risk recorded in men (OR 0.96, 95% CI 0.90-1.02). The inconsistent results between men and women and the absence of association in both sexes combined indicate that the apparent association between processed meat and bladder cancer in women is unlikely to be causal.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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