25-Hydroxyvitamin D Serum Levels and Endometriosis: Results of a Case-Control Study
Buggio L, Somigliana E, Pizzi MN, Dridi D, Roncella E, Vercellini P
Reproductive sciences (Thousand Oaks, Calif.) · 21 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-03-27 · Reprod Sci · vol. 26 · issue 2 · pp. 172–177
- Publisher
- Springer Nature
- Cited
- 39 citations · more than 92% of similar papers · 3.6× the field average
- Impact
- Top 10% most cited in its field
- References
- 32 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Endometriosis Research and Treatment · Vitamin D Research Studies · Uterine Myomas and Treatments
- Keywords
- Endometriosis, Medicine, Vitamin D and neurology, Internal medicine, Case-control study, Pathogenesis, vitamin D deficiency, Gastroenterology, Gynecology
- MeSH
- humans, ovarian diseases, endometriosis, vitamin d deficiency, vitamin d, case-control studies, adolescent, adult, middle aged, female, young adult
6 authors
From IT
- Laura Buggio · correspondingFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Edgardo SomiglianaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Mara Nicoletta PizziFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Dhouha DridiFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Elena RoncellaFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
- Paolo VercelliniFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
Abstract
The immunomodulatory, anti-inflammatory, and antiproliferative properties of vitamin D have laid the basis for a possible function of this prohormone in the pathogenesis of endometriosis. The aim of this case-control study was to investigate vitamin D status, by measuring 25-hydroxyvitamin D [25(OH)D] serum levels, in women with and without endometriosis. Only Italian women of Caucasian origin aged between 18 and 45 years were deemed eligible. Enrollment was limited to the period October to May. Cases and controls were matched for month of recruitment and secondarily for age and parity. Overall, 434 women were enrolled (endometriosis n = 217; controls n = 217). The group of cases included 127 women with ovarian endometrioma and 90 patients with deep endometriosis. Mean (standard deviation) levels of 25(OH)D in women with and without endometriosis were 17.9 (7.0) ng/mL and 18.4 (7.6) ng/mL, respectively ( P = .46). Analyzing the two endometriosis subgroups separately, no statistically significant differences emerged (18.7 [7.4] ng/mL in deep endometriosis group vs 17.3 [6.6] ng/mL in women with ovarian endometrioma; P = .14). Comparing the subgroup of women with deep endometriosis with paired controls, no differences occurred (18.7 [7.4] ng/mL vs 18.5 [7.7] ng/mL, P = .80). Similar data emerged when performing the same analysis for ovarian endometriomas (17.4 [6.6] ng/mL vs 18.3 [7.6] ng/mL, P = .23). The results of the present case-control study do not support an association between serum vitamin D levels and different phenotypes of endometriosis.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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