Cruciferous and Total Vegetable Intakes Are Inversely Associated With Subclinical Atherosclerosis in Older Adult Women
Blekkenhorst LC, Bondonno CP, Lewis JR, Woodman RJ, Devine A, Bondonno NP, Lim WH, Zhu K, Beilin LJ, Thompson PL, Prince RL, Hodgson JM
Journal of the American Heart Association · 35 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
Based on full-text disclosure statement.
Publication
- Published
- 2018-04-04 · J Am Heart Assoc · vol. 7 · issue 8
- Publisher
- Wiley
- Cited
- 45 citations · more than 95% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Nuts composition and effects
- Keywords
- Medicine, Cruciferous vegetables, Subclinical infection, Common carotid artery, Intima-media thickness, Cohort, Food science, Internal medicine, Carotid arteries
- MeSH
- carotid artery, common, humans, vegetables, carotid artery diseases, prognosis, diet, risk factors, retrospective studies, follow-up studies, nutritive value, aged, female, plaque, atherosclerotic, carotid intima-media thickness
12 authors
From AU
- Lauren C. Blekkenhorst · correspondingEdith Cowan University; The University of Western Australia; Royal Perth Hospital; Queen Elizabeth II Medical Centre
- Catherine P. BondonnoEdith Cowan University; The University of Western Australia; Royal Perth Hospital
- Joshua Richard LewisEdith Cowan University; The University of Sydney; The University of Western Australia; Children's Hospital at Westmead; Queen Elizabeth II Medical Centre
- Richard John WoodmanFlinders University
- Amanda DevineEdith Cowan University
- Nicola P. BondonnoThe University of Western Australia; Royal Perth Hospital
Abstract
Background
Dietary patterns rich in fruits and vegetables are considered to reduce atherosclerotic disease presentation and are reported to be inversely associated with subclinical measures of atherosclerosis, such as carotid artery intima-media thickness (IMT) and plaque. However, the effect of vegetable intake alone, and relationships to specific types of vegetables containing different phytochemical profiles, is important. The aim of this study was to investigate the associations of total vegetable intake and specific vegetables grouped according to phytochemical constituents with common carotid artery IMT (CCA-IMT) and carotid plaque severity in a cohort of older adult women (aged ≥70 years).
Methods and results
Total vegetable intake was calculated at baseline (1998) using a validated food frequency questionnaire. Vegetable types included cruciferous, allium, yellow/orange/red, leafy green, and legumes. In 2001, CCA-IMT (n=954) and carotid focal plaque (n=968) were assessed using high-resolution B-mode carotid ultrasonography. Mean (SD) total vegetable intake was 199.9 (78.0) g/d. Women consuming ≥3 servings of vegetables each day had ≈4.6% to 5.0% lower mean CCA-IMT (P=0.014) and maximum CCA-IMT (P=0.004) compared with participants consuming PPP>0.05). No associations were observed between vegetables and plaque severity (P>0.05).
Conclusions
Increasing vegetables in the diet with a focus on consuming cruciferous vegetables may have benefits for the prevention of subclinical atherosclerosis in older adult women.
Clinical trial registration
URL: http://www.anzctr.org.au. Unique identifier: ACTRN12615000750583.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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