Nut consumption and incidence of seven cardiovascular diseases
Larsson SC, Drca N, Björck M, Bäck M, Wolk A
Heart (British Cardiac Society) · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Vetenskapsrådet
- Nonprofit
- STROKE-Riksförbundet
- Authors
- At least one author declares a financial tie to industry
- Grants
- Vetenskapsrådet (2015-02302); Vetenskapsrådet (2016-01042)
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-04-16 · Heart · vol. 104 · issue 19 · pp. 1615–1620
- Publisher
- BMJ
- Cited
- 39 citations · more than 92% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 33 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nuts composition and effects · Botany, Ecology, and Taxonomy Studies · Oral Health Pathology and Treatment
- Keywords
- Medicine, Atrial fibrillation, Internal medicine, Incidence (geometry), Stroke (engine), Heart failure, Cardiology, Myocardial infarction, Prospective cohort study, Risk factor, Nut, Surgery
- MeSH
- humans, nuts, cardiovascular diseases, atrial fibrillation, incidence, risk factors, follow-up studies, prospective studies, feeding behavior, qualitative research, aged, aged, 80 and over, middle aged, sweden, female, male, heart failure, outcome assessment, health care
5 authors
From SE
- Susanna C. Larsson · correspondingKarolinska Institutet
- Nikola DrcaKarolinska University Hospital; Karolinska Institutet
- Martin BjörckUppsala University
- Magnus BäckKarolinska University Hospital; Karolinska Institutet
- Alicja WolkUppsala University; Karolinska Institutet
Abstract
Background
Nut consumption has been found to be inversely associated with cardiovascular disease mortality, but the association between nut consumption and incidence of specific cardiovascular diseases is unclear. We examined the association between nut consumption and incidence of seven cardiovascular diseases.
Methods
This prospective study included 61 364 Swedish adults who had completed a Food Frequency Questionnaire and were followed up for 17 years through linkage with the Swedish National Patient and Death Registers.
Results
Nut consumption was inversely associated with risk of myocardial infarction, heart failure, atrial fibrillation and abdominal aortic aneurysm in the age-adjusted and sex-adjusted analysis. However, adjustment for multiple risk factors attenuated these associations and only a linear, dose-response, association with atrial fibrillation (ptrend=0.004) and a non-linear association (pnon-linearity=0.003) with heart failure remained. Compared with no consumption of nuts, the multivariable HRs (95% CI) of atrial fibrillation across categories of nut consumption were 0.97 (0.93 to 1.02) for 1-3 times/month, 0.88 (0.79 to 0.99) for 1-2 times/week and 0.82 (0.68 to 0.99) for ≥3 times/week. For heart failure, the corresponding HRs (95% CI) were 0.87 (0.80 to 0.94), 0.80 (0.67 to 0.97) and 0.98 (0.76 to 1.27). Nut consumption was not associated with risk of aortic valve stenosis, ischaemic stroke or intracerebral haemorrhage.
Conclusions
These findings suggest that nut consumption or factors associated with this nutritional behaviour may play a role in reducing the risk of atrial fibrillation and possibly heart failure.
Trial registration number
NCT01127711 and NCT01127698;Results.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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