The Role of Cruciferous Vegetables and Isothiocyanates for Lung Cancer Prevention: Current Status, Challenges, and Future Research Directions
Zhang Z, Bergan R, Shannon J, Slatore CG, Bobe G, Takata Y
Molecular nutrition & food research · 24 citations
How it was studied
- Design
- Meta-analysis (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Veterans Affairs
- University or hospital
- Knight Cancer Institute OHSU/OSU Cancer Prevention and Control Initiative
Based on 2 listed funder(s).
Publication
- Published
- 2018-04-17 · Mol Nutr Food Res · vol. 62 · issue 18 · p. e1700936
- Publisher
- Wiley
- Cited
- 29 citations · more than 74% of similar papers · 1.0× the field average
- References
- 104 works
- Access
- Paywalled
- Research areas
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Nitrogen and Sulfur Effects on Brassica
- Keywords
- Cruciferous vegetables, Lung cancer, Medicine, Cancer, Odds ratio, Confidence interval, Environmental health, Internal medicine, Sulforaphane, Oncology, Cancer research
- MeSH
- humans, brassicaceae, vegetables, lung neoplasms, isothiocyanates, anticarcinogenic agents, diet, risk factors, clinical trials as topic, biomarkers, observational studies as topic
6 authors
From US
- Zhenzhen ZhangOregon Health & Science University
- Raymond C. BerganOregon Health & Science University
- Jackilen ShannonOregon Health & Science University
- Christopher G. SlatoreOregon Health & Science University; VA Portland Health Care System
- Gerd BobeOregon State University
- Yumie Takata · correspondingOregon State University
Abstract
Lung cancer remains a leading cause of cancer-related deaths in the United States. Although smoking and air pollution exposure are primary risk factors of lung cancer, diet has also been reported to contribute to lung cancer risk. Cruciferous vegetables contain many bioactive compounds that alter the detoxification process of air-borne carcinogenic compounds and, thereby, may decrease lung cancer risk. In the meta-analysis of 31 observational studies, cruciferous vegetable intake is inversely associated with lung cancer risk (summary odds ratio/relative risk = 0.81 and 95% confidence interval = 0.74-0.89 for comparing the highest with lowest intake categories). More observational studies need to measure urinary isothiocyanate (ITC) concentrations and investigate their association with lung cancer risk in populations with relatively high intake of cruciferous vegetables. Current evidence is limited to two phase 2 clinical trials with incomplete reporting. Hence, more short-term clinical phase 2 trials need to examine effects of various amounts and types of cruciferous vegetables on biomarkers of risk and efficacy before a large phase 3 trial can be conducted to assess effects upon lung cancer risk. This would help further elucidate whether the inverse association observed with self-reported cruciferous vegetable intake is indeed due to ITC content or other bioactive compounds.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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