The CYP1A2 -163C>A polymorphism does not alter the effects of caffeine on basketball performance
Puente C, Abián-Vicén J, Del Coso J, Lara B, Salinero JJ
PloS one · 40 citations
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Vice Rectorate of Science, Camilo José Cela University
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-04-18 · PLoS One · vol. 13 · issue 4 · p. e0195943
- Publisher
- Public Library of Science
- Cited
- 56 citations · more than 96% of similar papers · 4.8× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Coffee research and impacts · Genetics and Physical Performance · Muscle metabolism and nutrition
- Keywords
- Basketball, Caffeine, Allele, Genotype, CYP1A2, Sprint, Polymorphism (computer science), Medicine, Internal medicine, Genetics, Psychology, Biology, Physical therapy, Metabolism, Gene
- MeSH
- humans, caffeine, cytochrome p-450 cyp1a2, pharmacogenetics, genotype, polymorphism, single nucleotide, alleles, basketball, adult, female, male, athletic performance, young adult, genetic association studies, pharmacogenomic variants
5 authors
From ES
- Carlos PuenteCamilo José Cela University
- Javier Abián‐VicénCamilo José Cela University; University of Castilla-La Mancha
- Juan Del Coso · correspondingCamilo José Cela University
- Beatriz LaraCamilo José Cela University
- Juan José SalineroCamilo José Cela University
Abstract
Purpose
The aim of this investigation was to analyze the influence of the genetic variations of the -163C>A polymorphism of the CYP1A2 gene on the ergogenic effects of caffeine in elite basketball players.
Methods
Nineteen elite basketball players (10 men and 9 women) ingested 3 mg⋅kg-1 of caffeine or a placebo 60 min before performing 10 repetitions of the following series: the Abalakov jump test followed by the Change-of-Direction and Acceleration Test (CODAT). The players then competed in a 20-min simulated basketball game. Self-perceived performance and side effects were recorded by questionnaires after the trials. The effects of caffeine on basketball performance were established according to players' CYP1A2 genotype (rs762551): AA homozygotes (n = 10) and C-allele carriers (n = 9).
Results
In the 10 repetitions, caffeine increased Abalakov jump height by a mean of 2.9±3.6% in AA homozygotes (p = 0.03) while this effect did not reach statistical significance for C-allele carriers (2.3 ± 6.8%; p = 0.33). Caffeine did not affect sprint time in the CODAT test in either genotype group but it increased the number of impacts performed during the simulated game in both AA homozygotes (4.1 ± 5.3%; p = 0.02) and C-allele carriers (3.3 ± 3.2%; p = 0.01). During the 24 h following the test, AA homozygotes tended to experience increased insomnia with caffeine while C-allele carriers did not present this effect. The remaining variables were unaffected by the genotype.
Conclusion
The CYP1A2 -163C>A polymorphism minimally altered the ergogenicity derived from the consumption of a moderate dose of caffeine in elite basketball players.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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