Plasma 25-hydroxyvitamin D concentration and risk of type 2 diabetes and pre-diabetes: 12-year cohort study
Park SK, Garland CF, Gorham ED, BuDoff L, Barrett-Connor E
PloS one · 43 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- University or hospital
- University of California, San Diego
- Government
- National Institute on Aging
- Government
- National Institute of Diabetes and Digestive and Kidney Diseases
- Government
- NIA NIH HHS
- Government
- NIH HHS
- Government
- NIDDK NIH HHS
- Grants
- National Institute on Aging (R01 AG028507); National Institute on Aging (AG07181); National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK031801); National Institute of Diabetes and Digestive and Kidney Diseases (DK-31801); National Institute on Aging (AG028507); National Institute of Diabetes and Digestive and Kidney Diseases (AG07181); National Institute on Aging (R37 AG007181); National Institute on Aging (R01 AG007181); National Institutes of Health (AG028507); National Institutes of Health (AG07181); National Institutes of Health (DK31801)
Based on 7 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-04-19 · PLoS One · vol. 13 · issue 4 · p. e0193070
- Publisher
- Public Library of Science
- Cited
- 70 citations · more than 98% of similar papers · 6.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 57 works
- Access
- Open access (journal) · PUBLIC-DOMAIN
- Research areas
- Vitamin D Research Studies · Diabetes and associated disorders · HIV-related health complications and treatments
- Keywords
- Medicine, Diabetes mellitus, Type 2 diabetes, Internal medicine, Hazard ratio, Cohort, Endocrinology, Vitamin D and neurology, Cohort study, Gastroenterology, Confidence interval
- MeSH
- humans, diabetes mellitus, type 2, prediabetic state, calcium, vitamin d, glucose tolerance test, risk factors, cohort studies, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male
5 authors
From KR, US
- Sue K. ParkSeoul National University
- Cedric F. Garland · correspondingUniversity of California San Diego
- Edward Doerr GorhamUniversity of California San Diego
- Luke BuDoffUniversity of California San Diego
- Elizabeth L Barrett-ConnorUniversity of California San Diego
Abstract
Background
It has been reported that higher plasma 25-hydroxyvitamin D is associated with lower risk of type 2 diabetes. However the results to date have been mixed and no adequate data based on a cohort are available for the high end of the normal range, above approximately 32 ng/ml or 80 nmol/L.
Methods
We performed a cohort study of 903 adults who were known to be free of diabetes or pre-diabetes during a 1997-1999 visit to a NIH Lipid Research Centers clinic. Plasma 25(OH)D was measured at Visit 8 in 1977-1979. The mean age was 74 years. The visit also included fasting plasma glucose and oral glucose tolerance testing. Follow-up continued through 2009.
Results
There were 47 cases of diabetes and 337 cases of pre-diabetes. Higher 25(OH)D concentrations (> 30 ng/ml) were associated with lower hazard ratios (HR) for diabetes: 30-39 ng/ml or 75-98 nmol/L: HR = 0.31, 95% CI = 0.14-0.70; for 40-49 ng/ml or 100-122 nmol/L: HR = 0.29, CI = 0.12-0.68; for > 50 ng/ml or 125 nmol/L: HR = 0.19, CI = 0.06-0.56. All HRs are compared to < 30 ng/ml or 75 nmol/L. There was an inverse dose-response gradient between 25(OH)D concentration and risk of diabetes with a p for trend of 0.005. Each 10 ng/mL or 25 nmol/L higher 25(OH)D concentration was associated with a HR of 0.64, CI = 0.48-0.86. 25(OH)D concentrations were more weakly inversely associated with pre-diabetes risk, and the trend was not significant.
Conclusion
Further research is needed on whether high 25(OH)D might prevent type 2 diabetes or transition of prediabetes to diabetes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC0).
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