Comparative Study of Predominant Phytochemical Compounds and Proapoptotic Potential of Broccoli Sprouts and Florets
Paśko P, Tyszka-Czochara M, Galanty A, Gdula-Argasińska J, Żmudzki P, Bartoń H, Zagrodzki P, Gorinstein S
Plant foods for human nutrition (Dordrecht, Netherlands) · 40 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-04-19 · Plant Foods Hum Nutr · vol. 73 · issue 2 · pp. 95–100
- Publisher
- Springer Science+Business Media
- Cited
- 59 citations · more than 84% of similar papers · 1.7× the field average
- References
- 34 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Genomics, phytochemicals, and oxidative stress · Phytochemicals and Antioxidant Activities · Bioactive Compounds and Antitumor Agents
- Keywords
- Phytochemical, Sulforaphane, Chemistry, Food science, DPPH, Cytotoxic T cell, Antioxidant, Biochemistry, Botany, Traditional medicine, Biology, In vitro
- MeSH
- cell line, tumor, humans, brassica, flowers, isothiocyanates, sulfoxides, anticarcinogenic agents, freeze drying, cell death, organ specificity, polyphenols, phytochemicals, seedlings
8 authors
From PL, IL
- Paweł Paśko · correspondingJagiellonian University
- Małgorzata Tyszka‐CzocharaJagiellonian University
- Agnieszka GalantyJagiellonian University
- Joanna Gdula‐ArgasińskaJagiellonian University
- Paweł ŻmudzkiJagiellonian University; Medicina
- H. BartońJagiellonian University
Abstract
The study compares lyophilized broccoli sprouts and florets in terms of their chemical composition, cytotoxic and proapoptotic potential against hepatocellular carcinoma HepG2, colorectal cancer SW480, and skin fibroblast BJ cells. Sinapic and isochlorogenic acids were predominant phenolics in the sprouts and florets, respectively. The amount of sulforaphane in the sprouts was significantly higher vs. florets. Oleic and linoleic acids dominated in the sprouts, while caproic, stearic and oleic acids in the florets. Broccoli sprouts were selectively cytotoxic on HepG2 and SW480 cells, with proapoptotic effect for the latter, while the florets were less selective, but more active, with profound proapoptotic effect for HepG2 cells (77.4%). Thus, lyophilized broccoli sprouts may be effectively used in dietary chemoprevention.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.