Antioxidant and Anti-Inflammatory Effects of Blueberry Anthocyanins on High Glucose-Induced Human Retinal Capillary Endothelial Cells
Huang W, Huang W, Yan Z, Li D, Ma Y, Zhou J, Sui Z
Oxidative medicine and cellular longevity · 100 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- In vitro/mechanistic study (classified by our AI screen)
- Studied in
- Cells or lab samples
- Main outcome
- Mechanisms only
Who paid for it
- Funding
- Independent funding
- Government
- Jiangsu Agricultural Science and Technology Innovation Fund
- Government
- Government of Jiangsu Province
- Government
- Natural Science Foundation of Jiangsu Province
- Grants
- Jiangsu Agricultural Science and Technology Innovation Fund (CX(15)1026); Natural Science Foundation of Jiangsu Province (BK20161376)
Based on 3 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Oxid Med Cell Longev · vol. 2018 · issue 1 · p. 1862462
- Publisher
- Hindawi Publishing Corporation
- Cited
- 159 citations · more than 99% of similar papers · 13.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 40 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Retinal Diseases and Treatments · Glaucoma and retinal disorders · Advanced Glycation End Products research
- Keywords
- Chemistry, Reactive oxygen species, Antioxidant, Superoxide dismutase, Malvidin, Nitric oxide, Retinal, Biochemistry, Vascular endothelial growth factor, Catalase, NOX4, Pharmacology, NADPH oxidase, Biology, Cyanidin, Internal medicine, Medicine
- MeSH
- endothelial cells, humans, anthocyanins, catalase, superoxide dismutase, glucose, vascular endothelial growth factor a, anti-inflammatory agents, antioxidants, cell survival, blueberry plants
6 authors
From CN
- Wuyang HuangJiangsu Academy of Agricultural Sciences
- Zheng YanJiangsu Academy of Agricultural Sciences
- Dajing LiJiangsu Academy of Agricultural Sciences
- Yanhong MaJiangsu Academy of Agricultural Sciences
- Jianzhong Zhou · correspondingJiangsu Academy of Agricultural Sciences
- Zhongquan Sui · correspondingShanghai Jiao Tong University
Abstract
Blueberries possess abundant anthocyanins, which benefit eye health. The purpose of this study was to explore the protective functional role of blueberry anthocyanin extract (BAE) and its predominant constituents, malvidin (Mv), malvidin-3-glucoside (Mv-3-glc), and malvidin-3-galactoside (Mv-3-gal), on high glucose- (HG-) induced injury in human retinal capillary endothelial cells (HRCECs). The results showed that BAE, Mv, Mv-3-glc, and Mv-3-gal enhanced cell viability (P P P P P P P P κB) (P < 0.05). It indicated that blueberry anthocyanins protected HRCECs via antioxidant and anti-inflammatory mechanisms, which could be promising molecules for the development of nutraceuticals to prevent diabetic retinopathy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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