Kidney-protective Effect of Magnesium Supplementation in Cisplatin-containing Chemotherapy for Pediatric Cancer: A Retrospective Study
Matsui M, Saito Y, Yamaoka S, Yokokawa Y, Morikawa Y, Makimoto A, Yuza Y
Journal of pediatric hematology/oncology · 14 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-04-20 · J Pediatr Hematol Oncol · vol. 40 · issue 5 · pp. 379–381
- Publisher
- Lippincott Williams & Wilkins
- Cited
- 15 citations · more than 72% of similar papers · 0.9× the field average
- References
- 16 works
- Access
- Paywalled
- Research areas
- Chemotherapy-induced organ toxicity mitigation · Magnesium in Health and Disease · Pharmacological Effects and Toxicity Studies
- Keywords
- Medicine, Nephrotoxicity, Cisplatin, Chemotherapy, Odds ratio, Incidence (geometry), Creatinine, Confidence interval, Internal medicine, Retrospective cohort study, Urology, Cancer, Gastroenterology, Kidney
- MeSH
- humans, neoplasms, kidney diseases, cisplatin, magnesium, creatinine, retrospective studies, child, child, preschool, female, male
7 authors
From JP
- Motohiro Matsui · corresponding
- Yuya Saito · corresponding
- Shoko Yamaoka · corresponding
- Yuichi Yokokawa · corresponding
- Yoshihiko MorikawaTokyo Metropolitan Children's Medical Center
- Atsushi Makimoto · corresponding
Abstract
In total, 158 chemotherapy courses containing cisplatin for 37 pediatric cases of newly diagnosed cancer were divided into 2 groups depending on whether magnesium (Mg) supplementation was administered (Mg+: 92 courses) or not (Mg-: 66 courses). Renal impairment was defined as grade 2 or higher creatinine elevation (CE) after each chemotherapy course. The incidence of CE in the Mg+ was significantly lower than in the Mg- (9.8% vs. 22.7%; P=0.025). Multivariate analysis revealed that Mg supplementation significantly reduced the incidence of CE (odds ratio, 0.36; confidence interval, 0.13-0.99). In pediatric patients, Mg supplementation during cisplatin-containing chemotherapy was associated with less cisplatin-induced nephrotoxicity to prevent cisplatin-induced nephrotoxicity.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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