Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study
Papadopoulou E, Botton J, Brantsæter AL, Haugen M, Alexander J, Meltzer HM, Bacelis J, Elfvin A, Jacobsson B, Sengpiel V
BMJ open · 41 citations
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Institute of Neurological Disorders and Stroke
- Government
- National Institute of Environmental Health Sciences
- Nonprofit
- Stiftelsen Sigurd och Elsa Goljes Minnesfond
- Nonprofit
- Stiftelsen Fru Mary von Sydows, född Wijk, donationsfond
- Nonprofit
- Wilhelm och Martina Lundgrens Vetenskapsfond
- Government
- NIEHS NIH HHS
- Government
- NINDS NIH HHS
- Grants
- National Institute of Environmental Health Sciences (N01 ES075558); National Institute of Neurological Disorders and Stroke (U01 NS047537)
Based on 7 listed funder(s).
Publication
- Published
- 2018-03-01 · BMJ Open · vol. 8 · issue 3 · p. e018895
- Publisher
- BMJ
- Cited
- 73 citations · more than 96% of similar papers · 5.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 61 works
- Access
- Open access (journal) · CC-BY-NC
- Research areas
- Coffee research and impacts · Gestational Diabetes Research and Management · Cancer Risks and Factors
- Keywords
- Medicine, Overweight, Pregnancy, Prospective cohort study, Body mass index, Cohort study, Weight gain, Cohort, Obstetrics, Confounding, Birth weight, Obesity, Pediatrics, Offspring, Demography, Internal medicine, Body weight
- MeSH
- humans, prenatal exposure delayed effects, weight gain, caffeine, risk factors, cohort studies, prospective studies, child development, pregnancy, eating, child, child, preschool, infant, infant, newborn, diet records, norway, female, overweight
10 authors
From NO, FR, SE
- Eleni Zoumpoulia Papadopoulou · correspondingNorwegian Institute of Public Health
- Jérémie BottonUniversité Paris-Sud; Inserm; Université Paris Cité; Université Paris-Saclay; Sorbonne Paris Cité; Centre de Recherche Épidémiologie et Statistique
- Anne Lise BrantsæterNorwegian Institute of Public Health
- Margaretha A. HaugenNorwegian Institute of Public Health
- Jan AlexanderNorwegian Institute of Public Health
- Helle Margrete MeltzerNorwegian Institute of Public Health
Abstract
Objectives
To study the association between maternal caffeine intake during pregnancy and the child's weight gain and overweight risk up to 8 years.
Design
Prospective nationwide pregnancy cohort.
Setting
The Norwegian Mother and Child Cohort Study.
Participants
A total of 50 943 mothers recruited from 2002 to 2008 and their children, after singleton pregnancies, with information about average caffeine intake assessed at mid-pregnancy.
Outcome measure
Child's body size information at 11 age points from 6 weeks to 8 years. We defined excess growth in infancy as a WHO weight gain z-score of >0.67 from birth to age 1 year, and overweight according to the International Obesity Task Force. We used a growth model to assess individual growth trajectories.
Results
Compared with pregnant women with low caffeine intake (200 mg/day had consistently higher weight. Very high caffeine exposures were associated with higher weight gain velocity from infancy to age 8 years.
Conclusion
Any caffeine consumption during pregnancy is associated with a higher risk of excess infant growth and of childhood overweight, mainly at preschool ages. Maternal caffeine intake may modify the overall weight growth trajectory of the child from birth to 8 years. This study adds supporting evidence for the current advice to reduce caffeine intake during pregnancy.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC).
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