Evaluation of Biodistribution of Sulforaphane after Administration of Oral Broccoli Sprout Extract in Melanoma Patients with Multiple Atypical Nevi
Tahata S, Singh SV, Lin Y, Hahm ER, Beumer JH, Christner SM, Rao UN, Sander C, Tarhini AA, Tawbi H, Ferris LK, Wilson M, Rose A, Dietz CM, Hughes E, Fahey JW, Leachman SA, Cassidy PB, Butterfield LH, Zarour HM, Kirkwood JM
Cancer prevention research (Philadelphia, Pa.) · 66 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Institutes of Health
- Government
- National Cancer Institute
- Government
- NCI NIH HHS
- University or hospital
- Immunologic Monitoring and Cellular Products Laboratory
- Government
- NIH
- Grants
- National Cancer Institute (R21 CA161951); National Cancer Institute (P30 CA 047904); National Institutes of Health (R21CA161951)
Based on 5 listed funder(s).
Publication
- Published
- 2018-04-24 · Cancer Prev Res (Phila) · vol. 11 · issue 7 · pp. 429–438
- Publisher
- American Association for Cancer Research
- Cited
- 87 citations · more than 93% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 49 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Bioactive Compounds and Antitumor Agents · Immune Cell Function and Interaction
- Keywords
- Sulforaphane, Medicine, Melanoma, Toxicity, Pharmacology, Gastroenterology, Internal medicine, Cancer research
- MeSH
- skin, humans, brassica, melanoma, nevus, skin neoplasms, isothiocyanates, sulfoxides, plant extracts, capsules, biopsy, treatment outcome, administration, oral, feasibility studies, tissue distribution, pregnancy, adult, aged, middle aged, female, male, young adult, biomarkers, tumor
21 authors
From US
- Shawn TahataUPMC Hillman Cancer Center
- Shivendra Vikram SinghUniversity of Pittsburgh; UPMC Hillman Cancer Center
- Yan LinUPMC Hillman Cancer Center
- Eun‐Ryeong HahmUniversity of Pittsburgh
- Jan Hendrik BeumerUniversity of Pittsburgh; UPMC Hillman Cancer Center
- Susan M. ChristnerUPMC Hillman Cancer Center
Abstract
Broccoli sprout extract containing sulforaphane (BSE-SFN) has been shown to inhibit ultraviolet radiation-induced damage and tumor progression in skin. This study evaluated the toxicity and potential effects of oral BSE-SFN at three dosages. Seventeen patients who each had at least 2 atypical nevi and a prior history of melanoma were randomly allocated to 50, 100, or 200 μmol oral BSE-SFN daily for 28 days. Atypical nevi were photographed on days 1 and 28, and plasma and nevus samples were taken on days 1, 2, and 28. Endpoints assessed were safety, plasma and skin sulforaphane levels, gross and histologic changes, IHC for phospho-STAT3(Y705), Ki-67, Bcl-2, HMOX1, and TUNEL, plasma cytokine levels, and tissue proteomics. All 17 patients completed 28 days with no dose-limiting toxicities. Plasma sulforaphane levels pooled for days 1, 2, and 28 showed median postadministration increases of 120 ng/mL for 50 μmol, 206 ng/mL for 100 μmol, and 655 ng/mL for 200 μmol. Median skin sulforaphane levels on day 28 were 0.0, 3.1, and 34.1 ng/g for 50, 100, and 200 μmol, respectively. Plasma levels of proinflammatory cytokines decreased from day 1 to 28. The tumor suppressor decorin was increased from day 1 to 28. Oral BSE-SFN is well tolerated at daily doses up to 200 μmol and achieves dose-dependent levels in plasma and skin. A larger efficacy evaluation of 200 μmol daily for longer intervals is now reasonable to better characterize clinical and biological effects of BSE-SFN as chemoprevention for melanoma. Cancer Prev Res; 11(7); 429-38. ©2018 AACR.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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