Funded in part by DSM Nutritional Products Ltd., R&D Human Nutrition and Health
The association between 25-hydroxyvitamin D concentration, physical performance and frailty status in older adults
Vaes AMM, Brouwer-Brolsma EM, Toussaint N, de Regt M, Tieland M, van Loon LJC, de Groot LCPGM
European journal of nutrition · 37 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cross-sectional study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- University or hospital
- Top Institute Food and Nutrition
- Company
- DSM Nutritional Products Ltd., R&D Human Nutrition and Health
Based on 2 listed funder(s).
Publication
- Published
- 2018-04-24 · Eur J Nutr · vol. 58 · issue 3 · pp. 1173–1181
- Publisher
- Springer Science+Business Media
- Cited
- 64 citations · more than 96% of similar papers · 5.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 44 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Vitamin D Research Studies · Nutrition and Health in Aging · GDF15 and Related Biomarkers
- Keywords
- Vitamin D and neurology, Medicine, Grip strength, vitamin D deficiency, Population, Cross-sectional study, Internal medicine, Timed Up and Go test, Physical therapy, Environmental health, Pathology
- MeSH
- humans, vitamin d, hand strength, geriatric assessment, cross-sectional studies, aged, frail elderly, netherlands, female, male, frailty, physical functional performance
7 authors
From NL
- Anouk M.M. Vaes · correspondingTiFN; Wageningen University & Research
- Elske Maria Brouwer-BrolsmaWageningen University & Research
- Nicole ToussaintWageningen University & Research
- Margot de RegtWageningen University & Research
- Michael TielandTiFN; Wageningen University & Research
- Luc J. C. van LoonMaastricht University Medical Centre; Maastricht University; TiFN
Abstract
Purpose
Sufficient 25-hydroxyvitamin D (25(OH)D) concentrations might prevent a decline in physical performance, and are considered important for the prevention of frailty. This study investigates the association of serum 25(OH)D concentration with physical performance and frailty status in Dutch older adults.
Methods
This cross-sectional study included 756 men and women, aged ≥ 65 years. Serum 25(OH)D concentration and frailty status (Fried criteria) were assessed in the total population. Screening for frailty status included functional tests of gait speed and hand grip strength. In a subgroup (n = 494), the Timed Up and Go test (TUG) and knee-extension strength were measured. Associations of serum 25(OH)D status with physical performance were examined by multiple linear regression. Prevalence ratios (PR) were used to quantify associations between serum 25(OH)D deficiency (< 50 nmol/L) and frailty.
Results
In total, 45% of the participants were vitamin D deficient. Participants with vitamin D status 75 nmol/L. No significant associations with serum 25(OH)D concentrations were observed for handgrip strength or knee-extension strength. Participants with serum 25(OH)D status < 50 nmol/L were about two times more likely to be frail compared to participants with serum 25(OH)D status ≥ 50 nmol/L. No significant associations were observed between the pre-frail state and serum 25(OH)D status.
Conclusion
In this study, serum 25(OH)D concentrations were significantly associated with frailty status and measures of physical performance, including gait speed and TUG, but not with strength-related outcomes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.