Caffeine intake reduces incident atrial fibrillation at a population level
Casiglia E, Tikhonoff V, Albertini F, Gasparotti F, Mazza A, Montagnana M, Danese E, Benati M, Spinella P, Palatini P
European journal of preventive cardiology · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-04-25 · Eur J Prev Cardiol · vol. 25 · issue 10 · pp. 1055–1062
- Publisher
- Oxford University Press
- Cited
- 37 citations · more than 92% of similar papers · 3.2× the field average
- Impact
- Top 10% most cited in its field
- References
- 26 works
- Access
- Paywalled
- Research areas
- Coffee research and impacts · Cardiac pacing and defibrillation studies · Atrial Fibrillation Management and Outcomes
- Keywords
- Medicine, Atrial fibrillation, Caffeine, Internal medicine, Hazard ratio, Population, Rotterdam Study, Cardiology, Prospective cohort study, Cohort, Cohort study, Incidence (geometry), Confidence interval
- MeSH
- humans, atrial fibrillation, caffeine, cytochrome p-450 cyp1a2, central nervous system stimulants, incidence, risk factors, prospective studies, age factors, comorbidity, genotype, polymorphism, genetic, time factors, middle aged, italy, female, male, protective factors, pharmacogenomic variants
10 authors
From IT
- Edoardo Casiglia · correspondingUniversity of Padua
- Valérie TikhonoffUniversity of Padua
- Federica AlbertiniUniversity of Padua
- Federica GasparottiUniversity of Padua
- Alberto MazzaOspedale Santa Maria della Misericordia di Rovigo
- Martina MontagnanaUniversity of Verona
Abstract
Background The general belief is that caffeine increases the risk of hyperkinetic arrhythmias, including atrial fibrillation. The aim of this study is to investigate the effect of chronic caffeine intake on incident atrial fibrillation in general population. Design and methods A population cohort of 1475 unselected men and women observed for 12 years and left free to intake food or beverages containing caffeine was studied. Subjects were stratified into tertiles of caffeine intake both in the whole cohort and after genotyping for the -163C > A polymorphism of the CYP1A2 gene, regulating caffeine metabolism. Results In the whole cohort, the 12-year incidence of atrial fibrillation was significantly lower in the third (2.2%) than in the first (10.2%) or second (5.7%) tertile of caffeine intake ( P 165 mmol/day or > 320 mg/day) is associated with a lower incidence of atrial fibrillation in the 12-year epidemiological prospective setting based on the general population.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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