Usual Cruciferous Vegetable Consumption and Ovarian Cancer: A Case-Control Study
McManus H, Moysich KB, Tang L, Joseph J, McCann SE
Nutrition and cancer · 8 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case-control study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- National Cancer Institute
- University or hospital
- Roswell Park Cancer Institute and National Cancer Institute (NCI)
- Government
- NCI NIH HHS
- Grants
- National Cancer Institute (#P30 CA016056); National Cancer Institute (P50‐CA159981)
Based on 3 listed funder(s).
Publication
- Published
- 2018-04-25 · Nutr Cancer · vol. 70 · issue 4 · pp. 678–683
- Publisher
- Routledge
- Cited
- 8 citations · more than 42% of similar papers · 0.1× the field average
- References
- 22 works
- Access
- Open access (repository copy)
- Research areas
- Genomics, phytochemicals, and oxidative stress · Ovarian cancer diagnosis and treatment · Endometriosis Research and Treatment
- Keywords
- Cruciferous vegetables, Medicine, Ovarian cancer, Body mass index, Odds ratio, Confidence interval, Cancer, Logistic regression, Gynecology, Epidemiology, Environmental health, Internal medicine
- MeSH
- humans, vegetables, ovarian neoplasms, diet, case-control studies, adult, aged, middle aged, new york, female, surveys and questionnaires
5 authors
From US
- Hallie McManusHorace Mann School
- Kirsten B. MoysichRoswell Park Comprehensive Cancer Center
- Li TangRoswell Park Comprehensive Cancer Center
- Janine M. JosephRoswell Park Comprehensive Cancer Center
- Susan E. McCann · correspondingRoswell Park Comprehensive Cancer Center
Abstract
Ovarian cancer is the fifth leading cause of cancer-related deaths among women, primarily due to diagnosis at late stages. Therefore, identification of modifiable risk factors for this disease is warranted. Using the Patient Epidemiology Data System (PEDS), collected from 1981 to 1998 at Roswell Park Cancer Institute, Buffalo, NY, we conducted a hospital-based, case-control analysis of self-reported cruciferous vegetable intake and ovarian cancer among 675 women with primary, incident ovarian cancer, and 1275 without cancer. Cruciferous vegetable intake was queried using a 44-item food frequency questionnaire (FFQ). Odds ratios (OR) and 95% confidence intervals (CI) were estimated with logistic regression, adjusting for age, body mass index (BMI), education, smoking status, parity, family history of ovarian cancer, total fruit consumption, total meat consumption, and total noncruciferous vegetable consumption. We observed a significant inverse association for women with highest vs. lowest intakes of total vegetables (OR = 0.65, 95% CI = 0.46-0.92), cooked cauliflower (OR = 0.82, 95% CI = 0.67-0.99), and cooked greens (OR = 0.63, 95% CI = 0.46-0.86) and an inverse, dose-dependent association between cooked cruciferous vegetables intake and ovarian cancer (for each additional ten servings per month, OR = 0.85, 95% CI = 0.76-0.96). These findings suggest that a diet that includes cruciferous vegetables could be an important modifiable risk factor for ovarian cancer.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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