Effects of Astaxanthin and Docosahexaenoic-Acid-Acylated Astaxanthin on Alzheimer's Disease in APP/PS1 Double-Transgenic Mice
Che H, Li Q, Zhang T, Zhang T, Wang D, Yang L, Xu J, Yanagita T, Xue C, Chang Y, Wang Y
Journal of agricultural and food chemistry · 92 citations
How it was studied
- Design
- Animal study (classified by our AI screen)
- Studied in
- Animals
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Education of the People's Republic of China
- Government
- Japan Society for the Promotion of Science
- Government
- Government of Shandong Province
- Government
- Shandong Province
- Government
- Ministry of Education of the People's Republic of China
- Grants
- National Natural Science Foundation of China (U1606403); Ministry of Education of the People's Republic of China (201762028); National Natural Science Foundation of China (31330060); Japan Society for the Promotion of Science (16K00890); Government of Shandong Province (U1606403)
Based on 6 listed funder(s).
Publication
- Published
- 2018-04-25 · J Agric Food Chem · vol. 66 · issue 19 · pp. 4948–4957
- Publisher
- American Chemical Society
- Cited
- 150 citations · more than 97% of similar papers · 4.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Paywalled
- Research areas
- Antioxidant Activity and Oxidative Stress · Coenzyme Q10 studies and effects · Fatty Acid Research and Health
- Keywords
- Neuroinflammation, Docosahexaenoic acid, Astaxanthin, Morris water navigation task, Oxidative stress, Senile plaques, Pharmacology, Genetically modified mouse, Chemistry, Pathogenesis, Alzheimer's disease, Medicine, Transgene, Biochemistry, Endocrinology, Internal medicine, Fatty acid, Polyunsaturated fatty acid, Hippocampus, Disease
- MeSH
- animals, mice, transgenic, humans, mice, alzheimer disease, xanthophylls, docosahexaenoic acids, amyloid beta-protein precursor, learning, memory, acylation, female, male, presenilin-1
10 authors
From CN, JP
- Hongxia CheOcean University of China
- Qian LiOcean University of China
- Tiantian ZhangOcean University of China
- Dandan WangOcean University of China
- Lu YangOcean University of China
- Jie XuOcean University of China
Abstract
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with the characteristics of senile plaques, neuroinflammation, neurofibrillary tangles, and destruction of synapse structure stability. Previous studies have verified the protective effects of astaxanthin (AST). However, whether synthesized docosahexaenoic-acid-acylated AST diesters (AST-DHA) could delay AD pathogenesis remains unclear. In the present study, APP/PSEN1 (APP/PS1) double-transgenic mice were administrated with AST and AST-DHA for 2 months. The results of radial 8-arm maze and Morris water maze tests showed that AST-DHA exerted more significant effects than AST in enhancing learning and memory levels of APP/PS1 mice. Further mechanical studies suggested that AST-DHA was superior to AST in regulating the parameters of oxidative stress, reducing tau hyperphosphorylation, suppressing neuroinflammation, and regulating inflammasome expression and activation in APP/PS1 mice. The findings suggested that AST-DHA attenuated cognitive disorders by reducing pathological features in APP/PS1 mice, suggesting that AST-DHA might be a potential therapeutic agent for AD.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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