Longitudinal association between egg consumption and the risk of cardiovascular disease: interaction with type 2 diabetes mellitus
Jang J, Shin MJ, Kim OY, Park K
Nutrition & diabetes · 17 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Government
- Centers for Disease Control and Prevention
Based on 1 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-04-25 · Nutr Diabetes · vol. 8 · issue 1 · p. 20
- Publisher
- Springer Nature
- Cited
- 21 citations · more than 92% of similar papers · 3.3× the field average
- Impact
- Top 10% most cited in its field
- References
- 28 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Consumer Attitudes and Food Labeling · Phytoestrogen effects and research
- Keywords
- Medicine, Hazard ratio, Prospective cohort study, Confounding, Type 2 diabetes, Quartile, Internal medicine, Type 2 Diabetes Mellitus, Confidence interval, Diabetes mellitus, Proportional hazards model, Incidence (geometry), Cohort study, Disease, Cohort, Epidemiology, Longitudinal study, Endocrinology, Pathology
- MeSH
- humans, cardiovascular diseases, diabetes mellitus, type 2, diet, diet surveys, proportional hazards models, longitudinal studies, follow-up studies, prospective studies, feeding behavior, eggs, adult, aged, middle aged, female, male, republic of korea, surveys and questionnaires, asian people
4 authors
From KR
- Jiyoung JangYeungnam University
- Min‐Jeong ShinKorea University
- Oh Yoen KimDong-A University
- Kyong Park · correspondingYeungnam University
Abstract
Background/objectives
It remains unclear if high egg consumption has beneficial or adverse effects on cardiometabolic health. The present study prospectively evaluated the longitudinal association between egg-consumption levels and incident cardiovascular disease (CVD) among Korean adults.
Subjects/methods
We conducted a prospective cohort study of 9248 Korean adults aged 40-69 years without CVD or cancer at the baseline from the Korean Genome and Epidemiology Study, Ansung-Ansan cohort, South Korea. The egg intake of the participants was estimated using a validated semiquantitative food frequency questionnaire at the baseline and the second follow-up examination and categorized into quartiles. CVD cases were identified using biennial questionnaires and confirmed through repeated in-depth personal interviews. Hazard ratios (HR) and 95% confidence interval (CI) were analyzed using Cox proportional hazard regression.
Results
During the average follow-up of 7.3 years, 570 cases of CVD were newly diagnosed. After adjusting for multiple confounding variables, egg-intake levels were not associated with CVD incidence (HR: 1.14, 95% CI: 0.87-1.49, P for trend: 0.7). However, the association was modified by type 2 diabetes mellitus (T2DM) status. Egg consumption was significantly associated with an increased risk for incident CVD among participants with T2DM; individuals with the highest egg intake (4.2 ± 0.04 eggs/week) had a 2.8 times higher incidence of CVD (HR: 2.81, 95% CI: 1.25-6.30, P for trend: 0.02) than those with the lowest egg intake (0.1 ± 0.02 eggs/week). However, no association was observed among individuals without T2DM (HR: 1.03, 95% CI: 0.77-1.38, P for trend: 0.8).
Conclusions
Higher egg consumption may increase the risk for CVD in Korean patients with T2DM. Our findings provide a basis for the development of an optimal dietary cholesterol intake guideline for the Korean population.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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