Funded in part by Evolution Nutraceutical Company
Effect of Eicosapentaenoic Acid on Body Composition and Inflammation Markers in Patients with Head and Neck Squamous Cell Cancer from a Public Hospital in Mexico
Solís-Martínez O, Plasa-Carvalho V, Phillips-Sixtos G, Trujillo-Cabrera Y, Hernández-Cuellar A, Queipo-García GE, Meaney-Mendiolea E, Ceballos-Reyes GM, Fuchs-Tarlovsky V
Nutrition and cancer · 42 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- Evolution Nutraceutical Company
- Nonprofit
- Fundación Dr. Díaz Perches
Based on 2 listed funder(s).
Publication
- Published
- 2018-04-26 · Nutr Cancer · vol. 70 · issue 4 · pp. 663–670
- Publisher
- Routledge
- Cited
- 60 citations · more than 89% of similar papers · 2.5× the field average
- References
- 30 works
- Access
- Paywalled
- Research areas
- Nutrition and Health in Aging · Head and Neck Cancer Studies · Fatty Acid Research and Health
- Keywords
- Medicine, Lean body mass, Bioelectrical impedance analysis, Head and neck cancer, Eicosapentaenoic acid, Internal medicine, Cachexia, Anorexia, Cancer, Placebo, Gastroenterology, Surgery, Body mass index, Body weight, Pathology, Polyunsaturated fatty acid, Fatty acid, Biology
- MeSH
- humans, head and neck neoplasms, inflammation, body weight, eicosapentaenoic acid, interleukin-8, body composition, quality of life, dietary supplements, adult, aged, middle aged, mexico, interferon-gamma, biomarkers, squamous cell carcinoma of head and neck
9 authors
From MX
- Obed Solís-MartínezInstituto Politécnico Nacional
- Valentina Plasa-CarvalhoHospital General de México
- Geraldine Phillips-SixtosHospital General de México
- Yanelly Trujillo-CabreraHospital General de México
- Arturo Hernández-CuéllarHospital General de México
- Gloria Eugenia Queipo-GarcíaHospital General de México
Abstract
Introduction
Head and neck cancer patients are at high risk of anorexia-cachexia syndrome and literature shows that Eicosapentaenoic acid (EPA) could regulate it. We aim to determine the EPA effect on body composition and pro-inflammatory markers in patients with head neck cancer.
Materials and methods
A randomized single-blind placebo-controlled clinical trial was conducted in patients with head and neck squamous cell cancer who received a polymeric diet with 2 g of EPA or a standard polymeric diet for six weeks before antineoplastic treatment. We assessed body composition by bioelectrical impedance analysis and determined IL-1β, IL-6, TNF-α and IFN-γ, CRP, serum proteins, and blood count at baseline and at the end of the study.
Results
32 patients received EPA (2 g/day) and 32 became controls. A decrease in serum levels of IL-1β, IL-6, TNF-α, and IFN-γ was observed in the experimental group, as well as regulation of body weight (-0.3 ± 5.9 vs. -2.1 ± 3.7), lean body mass (-0.2 ± 3.8 vs. -1.3 ± 3.6), body fat mass (0.2 ± 3.5 vs. -1.2 ± 3.8), and quality of life (10 ± 33 vs. 5 ± 34).
Conclusion
Supplementing with 2 g/day of EPA to head and neck cancer patient during antineoplastic treatment regulates serum pro-inflammatory cytokines, body weight, lean body mass, and improve quality of life.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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