Creatine monohydrate supplementation during eight weeks of progressive resistance training increases strength in as little as two weeks without reducing markers of muscle damage
Kaviani M, Abassi A, Chilibeck PD
The Journal of sports medicine and physical fitness · 11 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2019-03-01 · J Sports Med Phys Fitness · vol. 59 · issue 4 · pp. 608–612
- Publisher
- Edizioni Minerva Medica
- Cited
- 32 citations · more than 74% of similar papers · 1.2× the field average
- References
- 28 works
- Access
- Paywalled
- Research areas
- Muscle metabolism and nutrition · Cardiovascular and exercise physiology · Exercise and Physiological Responses
- Keywords
- Bench press, Creatine Monohydrate, Medicine, Creatine kinase, Leg press, Placebo, Muscle damage, Creatine, Resistance training, Strength training, Biceps, Lactate dehydrogenase, Physical strength, Internal medicine, Physical therapy, Surgery, Biology, Biochemistry, Pathology
- MeSH
- muscle, skeletal, humans, creatine, exercise, double-blind method, dietary supplements, adult, male, muscle strength, resistance training, young adult
3 authors
From CA, IR
- Mojtaba KavianiAcadia University
- Aboozar AbassiShiraz University
- Philip David ChilibeckUniversity of Saskatchewan
Abstract
Background
Creatine supplementation (Cr) increases strength during resistance training, but the time course of this strength increase is unclear. The aim was to determine the precise time course by which Cr could increase strength and whether Cr prevents muscle damage during eight weeks of resistance training.
Methods
Young males were randomized (double blind) to Cr (N.=9, 0.07g/kg/d) and placebo (N.=9) during 8-weeks of resistance training (3 d/week). Strength was assessed across six exercises every two weeks. Venous blood samples obtained at baseline, and 24 and 48 hours after the final resistance training session were assessed for creatine kinase [CK] and lactate dehydrogenase [LDH] as measures of muscle damage.
Results
Strength was significantly higher in the Cr versus placebo group (P<0.05) after two weeks of training for three of the six exercises (bench press, leg press, shoulder press). By the end of the eight weeks of training, strength was significantly higher in the Cr versus placebo group (P<0.05) for four of the six exercises (bench press, leg press, shoulder press, and triceps extension, but not biceps curl or lat-pulldown). Creatine supplementation did not prevent muscle damage. Indeed, muscle damage markers increased in the Cr compared to placebo group (P<0.05).
Conclusions
Cr increased muscular strength in as little as two weeks during a resistance training program; however, this was not accompanied by decreased muscle damage. Greater muscle damage with Cr may be due to a greater training intensity enabled by Cr supplementation. This might lead to greater protein turnover and enhanced muscle adaptation.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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