Effect of dietary nitrate supplementation on conduit artery blood flow, muscle oxygenation, and metabolic rate during handgrip exercise
Craig JC, Broxterman RM, Smith JR, Allen JD, Barstow TJ
Journal of applied physiology (Bethesda, Md. : 1985) · 30 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- National Aeronautics and Space Administration
- University or hospital
- College of Veterinary Medicine, Kansas State University
- Government
- National Aeronautics and Space Administration (NASA)
- Grants
- National Aeronautics and Space Administration (NNX11AM05A); National Aeronautics and Space Administration (NNX10AK60G)
Based on 3 listed funder(s).
Publication
- Published
- 2018-05-03 · J Appl Physiol (1985) · vol. 125 · issue 2 · pp. 254–262
- Publisher
- American Physiological Society
- Cited
- 35 citations · more than 94% of similar papers · 4.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 51 works
- Access
- Free to read
- Research areas
- Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control · Nitric Oxide and Endothelin Effects
- Keywords
- Crossover study, Internal medicine, Nitrate, Heart rate, Dietary Nitrate, Placebo, Blood pressure, Myoglobin, Endocrinology, Hemoglobin, Oxygenation, Medicine, Exercise physiology, Cardiology, Chemistry, Nitrite, Biochemistry
- MeSH
- muscle, skeletal, brachial artery, animals, humans, rats, nitrates, hemoglobins, myoglobin, exercise test, hand strength, cross-over studies, double-blind method, oxygen consumption, blood pressure, regional blood flow, exercise tolerance, muscle contraction, dietary supplements, adult, female, male
5 authors
From US
- Jesse C. Craig · correspondingKansas State University
- Ryan Michael BroxtermanKansas State University
- Joshua R. SmithKansas State University
- Jason David AllenDuke Medical Center; University of Virginia
- Thomas Jackson BarstowKansas State University
Abstract
Dietary nitrate supplementation has positive effects on mitochondrial and muscle contractile efficiency during large muscle mass exercise in humans and on skeletal muscle blood flow (Q̇) in rats. However, concurrent measurement of these effects has not been performed in humans. Therefore, we assessed the influence of nitrate supplementation on Q̇ and muscle oxygenation characteristics during moderate- (40 %peak) and severe-intensity(85% peak) handgrip exercise in a randomized, double-blind, crossover design. Nine healthy men (age: 25 ± 2 yr) completed four constant-power exercise tests (2/intensity) randomly assigned to condition [nitrate-rich (nitrate) or nitrate-poor (placebo) beetroot supplementation] and intensity (40 or 85% peak). Resting mean arterial pressure was lower after nitrate compared with placebo (84 ± 4 vs. 89 ± 4 mmHg, P 0.05) but was elevated throughout 85% peak ( P 2) was not different at the end of exercise; however, the V̇o2 primary amplitude at the onset of exercise was elevated after nitrate for the 85% peak work rate (96 ± 20 vs. 72 ± 12 ml/min, P 2 kinetics in young adults but does not augment Q̇ or reduce steady-state V̇o2 during small muscle mass handgrip exercise. NEW & NOTEWORTHY We show that acute dietary nitrate supplementation via beetroot juice increases the amplitude and speed of local muscle V̇o2 on kinetics parameters during severe- but not moderate-intensity handgrip exercise. These changes were found in the absence of an increased blood flow response, suggesting that the increased V̇o2 was attained via improvements in fractional O2 extraction and/or spatial distribution of blood flow within the exercising muscle.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.