Funded in part by AstraZeneca, AstraZeneca HealthCare Foundation
Physiological responses to acute cold exposure in young lean men
Acosta FM, Martinez-Tellez B, Sanchez-Delgado G, Alcantara JMA, Acosta-Manzano P, Acosta-Manzano P, Morales-Artacho AJ, Ruiz JR
PloS one · 28 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Industry funded
- Company
- AstraZeneca
- Company
- AstraZeneca HealthCare Foundation
- Nonprofit
- Fundación Iberoamericana de Nutrición
- Government
- Ministerio de Economía y Competitividad
- University or hospital
- Universidad de Granada
- Government
- Instituto de Salud Carlos III
- Government
- Spanish Ministry of Education
- University or hospital
- University of Granada
- University or hospital
- Excellence actions: Units of Excellence; Unit of Excellence on Exercise and Health (UCEES).
- Government
- Fondo de Investigación Sanitaria del Instituto de Salud Carlos III
- Nonprofit
- Retos de la Sociedad
- Government
- Redes temáticas de investigación cooperativa RETIC
- Government
- Spanish Ministry of Economy and Competitiveness
- Government
- Fondos Estructurales de la Unión Europea (FEDER)
- Nonprofit
- Fundación Iberoamericana de Nutrición (FINUT)
- Grants
- Ministerio de Economía y Competitividad (PI13/01393); Instituto de Salud Carlos III (DEP2016-79512-R); Ministerio de Economía y Competitividad (DEP2016-79512-R); Universidad de Granada (PTA 12264-I); Universidad de Granada (n 2016); Universidad de Granada (DEP2016-79512-R); Ministerio de Economía y Competitividad (PTA 12264-I); Fundación Iberoamericana de Nutrición (RD16/0022); Instituto de Salud Carlos III (Red SAMID RD16/0022); Instituto de Salud Carlos III (RD16/0022); Instituto de Salud Carlos III (PTA-12264I); Instituto de Salud Carlos III (PI13/01393)
Based on 15 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-05-07 · PLoS One · vol. 13 · issue 5 · p. e0196543
- Publisher
- Public Library of Science
- Cited
- 42 citations · more than 88% of similar papers · 2.3× the field average
- References
- 69 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Thermoregulation and physiological responses · Exercise and Physiological Responses · Adipose Tissue and Metabolism
- Keywords
- Shivering, Thermoregulation, Medicine, Thermogenesis, Skin temperature, Animal science, Chemistry, Internal medicine, Anesthesia, Biology, Adipose tissue, Biomedical engineering
- MeSH
- humans, body mass index, body temperature, temperature, energy metabolism, oxygen consumption, body temperature regulation, thermogenesis, shivering, skin temperature, heart rate, adult, male, cold temperature, young adult
7 authors
From ES, NL
- Francisco M. Acosta · correspondingUniversidad de Granada
- Borja Martínez‐TéllezUniversidad de Granada; Leiden University Medical Center
- Guillermo Sánchez‐DelgadoUniversidad de Granada
- Juan M. A. AlcántaraUniversidad de Granada
- Pedro Acosta‐ManzanoUniversidad de Granada
- Antonio J. Morales‐ArtachoUniversidad de Granada
Abstract
The aim of this study was to comprehensively describe the physiological responses to an acute bout of mild cold in young lean men (n = 11, age: 23 ± 2 years, body mass index: 23.1 ± 1.2 kg/m2) to better understand the underlying mechanisms of non-shivering thermogenesis and how it is regulated. Resting energy expenditure, substrate metabolism, skin temperature, thermal comfort perception, superficial muscle activity, hemodynamics of the forearm and abdominal regions, and heart rate variability were measured under warm conditions (22.7 ± 0.2°C) and during an individualized cooling protocol (air-conditioning and water cooling vest) in a cold room (19.4 ± 0.1°C). The temperature of the cooling vest started at 16.6°C and decreased ~ 1.4°C every 10 minutes until participants shivered (93.5 ± 26.3 min). All measurements were analysed across 4 periods: warm period, at 31% and at 64% of individual´s cold exposure time until shivering occurred, and at the shivering threshold. Energy expenditure increased from warm period to 31% of cold exposure by 16.7% (P = 0.078) and to the shivering threshold by 31.7% (P = 0.023). Fat oxidation increased by 72.6% from warm period to 31% of cold exposure (P = 0.004), whereas no changes occurred in carbohydrates oxidation. As shivering came closer, the skin temperature and thermal comfort perception decreased (all P0.05). Furthermore, the superficial muscle activation increased at the shivering threshold. It is noteworthy that the largest physiological changes occurred during the first 30 minutes of cold exposure, when the participants felt less discomfort.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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