Acute dietary nitrate supplementation does not attenuate oxidative stress or the hemodynamic response during submaximal exercise in hypobaric hypoxia
Carriker CR, Rombach P, Stevens BM, Vaughan RA, Gibson AL
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 15 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-05-18 · Appl Physiol Nutr Metab · vol. 43 · issue 12 · pp. 1268–1274
- Publisher
- NRC Research Press
- Cited
- 17 citations · more than 80% of similar papers · 1.1× the field average
- References
- 66 works
- Access
- Open access (repository copy)
- Research areas
- High Altitude and Hypoxia · Cardiovascular and exercise physiology · Heart Rate Variability and Autonomic Control
- Keywords
- Heart rate, Crossover study, Medicine, Hypoxia (environmental), Placebo, Nitrite, Oxidative stress, Hemodynamics, Internal medicine, Blood pressure, Dietary Nitrate, Aerobic exercise, VO2 max, Nitric oxide, Animal science, Oxygen, Endocrinology, Chemistry, Nitrate, Biology
- MeSH
- humans, beta vulgaris, nitrites, oxygen, diet, oxidative stress, oxygen consumption, blood pressure, bicycling, dietary supplements, adult, male, young adult, fruit and vegetable juices, hypoxia
5 authors
From US
- Colin R. CarrikerHigh Point University; University of New Mexico
- Paige RombachHigh Point University
- Brooke M. StevensHigh Point University
- Roger A. VaughanHigh Point University
- Ann L. GibsonUniversity of New Mexico
Abstract
The purpose of this study was to investigate changes in oxidative stress, arterial oxygen saturation (SaO2), blood pressure (BP), and heart rate (HR) during exercise in hypobaric hypoxia following acute dietary nitrate supplementation. Nine well-trained (maximal oxygen consumption, 60.8 ± 7.8 mL·kg-1·min-1) males (age, 29 ± 7 years) visited the laboratory on 3 occasions, each separated by 1 week. Visit 1 included a maximal aerobic cycling test and five 5-min increasing-intensity exercise bouts in a normobaric environment (1600 m). A single dose of either a nitrate-depleted placebo (PL) or a nitrate-rich beverage (NR; 12.8 mmol nitrate) was consumed 2.5 h prior to exercise during visits 2 and 3 (3500 m) in a double-blind, placebo-controlled, crossover study consisting of a 5-min cycling warm-up and 4 bouts, each 5 min in duration, separated by 4-min periods of passive rest. Exercise wattages were determined during visit 1 and corresponded to 25%, 40%, 50%, 60%, and 70% of normobaric maximal oxygen consumption. Catalase and 8-isoprostane were measured before and after exercise (immediately before and 1 h postexercise, respectively). NR increased plasma nitrite (1.53 ± 0.83 μmol·L-1) compared with PL (0.88 ± 0.56 μmol·L-1) (p -1; NR, 23.23 ± 4.12 to 52.11 ± 19.76 pg·mL-1) and catalase (PL, 63.89 ± 25.69 to 128.15 ± 41.80 mmol·min-1·mL-1; NR, 78.89 ± 30.95 to 109.96 ± 35.05 mmol·min-1·mL-1) were elevated compared with baseline resting values (p 2, BP, or HR in healthy, aerobically fit men exercising at 3500 m.
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