Single Ultra-High-Dose Cholecalciferol to Prevent Vitamin D Deficiency in Pediatric Hematopoietic Stem Cell Transplantation
Wallace G, Jodele S, Myers KC, Dandoy CE, El-Bietar J, Nelson A, Teusink-Cross A, Khandelwal P, Taggart C, Gordon CM, Davies SM, Howell JC
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 23 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Controlled clinical trial (classified by our AI screen)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-05-18 · Biol Blood Marrow Transplant · vol. 24 · issue 9 · pp. 1856–1860
- Publisher
- Elsevier BV
- Cited
- 28 citations · more than 88% of similar papers · 2.3× the field average
- References
- 15 works
- Access
- Open access (hybrid journal) · CC-BY-NC-ND
- Research areas
- Vitamin D Research Studies · Pharmacological Effects and Toxicity Studies · Pregnancy and Medication Impact
- Keywords
- Medicine, Vitamin D and neurology, Transplantation, Hematopoietic stem cell transplantation, Mucositis, vitamin D deficiency, Gastroenterology, Internal medicine, Vitamin, Cholecalciferol, Surgery, Chemotherapy
- MeSH
- humans, vitamin d deficiency, cholecalciferol, transplantation conditioning, hematopoietic stem cell transplantation, adolescent, child, child, preschool, infant, female, male, calcium-regulating hormones and agents
12 authors
From US
- Gregory H. WallaceCincinnati Children's Hospital Medical Center; University of Cincinnati
- Sonata JodeleCincinnati Children's Hospital Medical Center; University of Cincinnati
- Kasiani C. MyersCincinnati Children's Hospital Medical Center; University of Cincinnati
- Christopher E. DandoyCincinnati Children's Hospital Medical Center; University of Cincinnati
- Javier Amin El-BietarCincinnati Children's Hospital Medical Center; University of Cincinnati
- Adam C. NelsonCincinnati Children's Hospital Medical Center; University of Cincinnati
Abstract
Vitamin D deficiency is prevalent among childhood hematopoietic stem cell transplantation (HSCT) recipients and associated with inferior survival at 100 days after transplantation. Achieving and maintaining therapeutic vitamin D levels in HSCT recipients is extremely challenging in the first 3 to 6 months after transplantation due to poor compliance in the setting of mucositis and the concomitant use of critical transplantation drugs that interfere with vitamin D absorption. We sought to evaluate the safety and efficacy of a single, ultra-high-dose of vitamin D given before childhood HSCT to maintain levels in a therapeutic range during the peritransplantation period. Ten HSCT recipients with pretransplantation 25-OH vitamin D (25OHD) level 30 ng/mL. Mean vitamin D levels were sustained at or above 30 ng/mL during the 8-week observation window. There were no electrolyte abnormalities attributed to the ultra-high-dose of vitamin D. Most patients had mildly elevated urine calcium/creatinine ratios during treatment, but none showed clinical or radiologic signs of nephrocalcinosis or nephrolithiasis. Our findings indicate that single ultra-high-oral dose vitamin D treatment given just before HSCT is safe and well tolerated in the immediate peritransplant period in children. Patients in our study were able to achieve and sustain therapeutic vitamin D levels throughout the critical period during which vitamin D insufficiency is associated with decreased overall survival. Larger prospective studies are needed to address the impact of single ultra-high-dose vitamin D treatment on HSCT outcomes.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY-NC-ND).
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