Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults
Qin C, Lv J, Guo Y, Bian Z, Si J, Yang L, Chen Y, Zhou Y, Zhang H, Liu J, Chen J, Chen Z, Yu C, Li L, China Kadoorie Biobank Collaborative Group
Heart (British Cardiac Society) · 95 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Food frequency questionnaire
Who paid for it
- Funding
- Independent funding
- Nonprofit
- Wellcome Trust
- University or hospital
- University of Oxford
- Government
- National Natural Science Foundation of China
- Government
- Ministry of Science and Technology of the People's Republic of China
- Nonprofit
- Kadoorie Charitable Foundation
- Government
- National Key Research and Development Program of China
- Government
- Medical Research Council
- Government
- Ministry of Science and Technology of the People’s Republic of China
- Grants
- National Natural Science Foundation of China (81390544); National Natural Science Foundation of China (81390540, 81390544, 81390541); Wellcome Trust (212946/Z/18/Z); National Natural Science Foundation of China (104085/Z/14/Z); Wellcome Trust (202922/Z/16/Z, 088158/Z/09/Z, 104085/Z/14/Z); National Key Research and Development Program of China (088158/Z/09/Z); University of Oxford (104085/Z/14/Z); Wellcome Trust (81390544); Wellcome Trust (202922/Z/16/Z); Ministry of Science and Technology of the People's Republic of China (202922/Z/16/Z); National Key Research and Development Program of China (202922/Z/16/Z); Kadoorie Charitable Foundation (81390541); National Natural Science Foundation of China (81390541); National Natural Science Foundation of China (202922/Z/16/Z); National Key Research and Development Program of China (104085/Z/14/Z); Wellcome Trust (088158/Z/09/Z); National Natural Science Foundation of China (088158/Z/09/Z); Ministry of Science and Technology of the People's Republic of China (088158/Z/09/Z); National Natural Science Foundation of China (81390540); Ministry of Science and Technology of the People's Republic of China (81390544); University of Oxford (202922/Z/16/Z); National Key Research and Development Program of China (81390544); Ministry of Science and Technology of the People's Republic of China (81390541); Wellcome Trust (104085/Z/14/Z); Kadoorie Charitable Foundation (202922/Z/16/Z); National Key Research and Development Program of China (81390541); National Key Research and Development Program of China (81390540); Ministry of Science and Technology of the People's Republic of China (81390540); Kadoorie Charitable Foundation (088158/Z/09/Z); Kadoorie Charitable Foundation (104085/Z/14/Z); Kadoorie Charitable Foundation (81390544); Ministry of Science and Technology of the People's Republic of China (104085/Z/14/Z); Wellcome Trust (81390540); Kadoorie Charitable Foundation (81390540); University of Oxford (088158/Z/09/Z); Wellcome Trust (81390541)
Based on 8 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-05-21 · Heart · vol. 104 · issue 21 · pp. 1756–1763
- Publisher
- BMJ
- Cited
- 130 citations · more than 99% of similar papers · 12.9× the field average
- Impact
- Top 10% most cited in its field
- References
- 35 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Nutritional Studies and Diet · Antioxidant Activity and Oxidative Stress · Consumer Attitudes and Food Labeling
- Keywords
- Medicine, Hazard ratio, Stroke (engine), Diabetes mellitus, Proportional hazards model, Internal medicine, Lower risk, Disease, Cohort study, Cohort, Confidence interval, Endocrinology
- MeSH
- humans, cardiovascular diseases, prevalence, multivariate analysis, logistic models, proportional hazards models, risk assessment, survival analysis, retrospective studies, cohort studies, risk reduction behavior, age factors, sex factors, eggs, adult, aged, middle aged, china, female, male, stroke
14 authors
From CN, GB, TW, US
- Chenxi QinPeking University; Faculty of Public Health
- Jun LvPeking University; Faculty of Public Health
- Canqing YuAcademy of Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College
- Zheng BianAcademy of Medical Sciences; Chinese Academy of Medical Sciences & Peking Union Medical College
- Jiahui SiPeking University; Faculty of Public Health
- Ling YangUniversity of Oxford; Nuffield Health
Abstract
Objective
To examine the associations between egg consumption and cardiovascular disease (CVD), ischaemic heart disease (IHD), major coronary events (MCE), haemorrhagic stroke as well as ischaemic stroke.
Methods
During 2004-2008, over 0.5 million adults aged 30-79 years were recruited from 10 diverse survey sites in China. Participants were asked about the frequency of egg consumption and were followed up via linkages to multiple registries and active investigation. Among 461 213 participants free of prior cancer, CVD and diabetes, a total of 83 977 CVD incident cases and 9985 CVD deaths were documented, as well as 5103 MCE. Stratified Cox regression was performed to yield adjusted hazard ratios for CVD endpoints associated with egg consumption.
Results
At baseline, 13.1% of participants reported daily consumption (usual amount 0.76 egg/day) and 9.1% reported never or very rare consumption (usual amount 0.29 egg/day). Compared with non-consumers, daily egg consumption was associated with lower risk of CVD (HR 0.89, 95% CI 0.87 to 0.92). Corresponding multivariate-adjusted HRs (95% CI) for IHD, MCE, haemorrhagic stroke and ischaemic stroke were 0.88 (0.84 to 0.93), 0.86 (0.76 to 0.97), 0.74 (0.67 to 0.82) and 0.90 (0.85 to 0.95), respectively. There were significant dose-response relationships of egg consumption with morbidity of all CVD endpoints (P for linear trend <0.05). Daily consumers also had an 18% lower risk of CVD death and a 28% lower risk of haemorrhagic stroke death compared to non-consumers.
Conclusion
Among Chinese adults, a moderate level of egg consumption (up to <1 egg/day) was significantly associated with lower risk of CVD, largely independent of other risk factors.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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