Osteoradionecrosis of the jaws: case series treated with adjuvant low-level laser therapy and antimicrobial photodynamic therapy
Ribeiro GH, Minamisako MC, Rath IBDS, Santos AMB, Simões A, Pereira KCR, Grando LJ
Journal of applied oral science : revista FOB · 39 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Cohort study (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-05-19 · J Appl Oral Sci · vol. 26 · issue 0 · p. e20170172
- Publisher
- University of São Paulo
- Cited
- 80 citations · more than 94% of similar papers · 3.7× the field average
- Impact
- Top 10% most cited in its field
- References
- 30 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Oral health in cancer treatment · Bone health and treatments · Oral Health Pathology and Treatment
- Keywords
- Osteoradionecrosis, Photodynamic therapy, Low level laser therapy, Medicine, Adjuvant therapy, Laser therapy, Radiation therapy, Antimicrobial, Dentistry, Surgery, Laser, Chemotherapy, Microbiology, Biology, Chemistry
- MeSH
- mouth mucosa, humans, jaw diseases, osteoradionecrosis, anti-infective agents, treatment outcome, photochemotherapy, prospective studies, reproducibility of results, dose-response relationship, radiation, wound healing, homeostasis, time factors, adult, aged, middle aged, female, male, chemoradiotherapy, adjuvant, low-level light therapy
7 authors
From BR
- GUILHERME HENRIQUE RIBEIROUniversidade Federal de Santa Catarina
- Mariana Comparotto MinamisakoCentro de Pesquisas Oncológicas
- Inês Beatriz da Silva RathUniversidade Federal de Santa Catarina
- Aira Maria Bonfim SantosUniversidade Federal de Santa Catarina
- Alyne SimõesUniversidade de Brasília; Universidade de São Paulo; Universidade Brasil
- Keila Cristina Rausch PereiraUniversidade do Sul de Santa Catarina
Abstract
Background
Osteoradionecrosis of the jaw (ORNJ) is the most severe and complex sequel of head and neck radiotherapy (RT) because of the bone involved, it may cause pain, paresthesia, foul odor, fistulae with suppuration, need for extra oral communication and pathological fracture. We treated twenty lesions of ORNJ using low-level laser therapy (LLLT) and antimicrobial photodynamic therapy (aPDT). The objective of this study was to stimulate the affected area to homeostasis and to promote the healing of the oral mucosa.
Methods
We performed aPDT on the exposed bone, while LLLT was performed around the bone exposure (red spectrum) and on the affected jaw (infrared spectrum). Monitoring and clinical intervention occurred weekly or biweekly for 2 years.
Results
100% of the sample presented clinical improvement, and 80% presented complete covering of the bone exposure by intact oral mucosa.
Conclusion
LLLT and aPDT showed positive results as an adjuvant therapy to treat ORNJ.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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