Vitamin D assays and the definition of hypovitaminosis D: results from the First International Conference on Controversies in Vitamin D
Sempos CT, Heijboer AC, Bikle DD, Bollerslev J, Bouillon R, Brannon PM, DeLuca HF, Jones G, Munns CF, Bilezikian JP, Giustina A, Binkley N
British journal of clinical pharmacology · 210 citations
How it was studied
- Design
- Expert or government fact sheet (classified by our AI screen)
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- U.S. Department of Veterans Affairs
- Government
- BLRD VA
- Grants
- U.S. Department of Veterans Affairs (I01 BX001066); U.S. Department of Veterans Affairs (I01 BX003814)
Based on 2 listed funder(s).
Publication
- Published
- 2018-05-31 · Br J Clin Pharmacol · vol. 84 · issue 10 · pp. 2194–2207
- Publisher
- Wiley
- Cited
- 337 citations · more than 100% of similar papers · 22.0× the field average
- Impact
- Top 10% most cited in its field
- References
- 121 works
- Access
- Open access (repository copy) · OTHER-OA
- Research areas
- Vitamin D Research Studies · Vitamin C and Antioxidants Research · Bone health and osteoporosis research
- Keywords
- Vitamin D and neurology, Hypovitaminosis, Osteomalacia, Calcifediol, Consensus conference, vitamin D deficiency, Medicine, Vitamin D-binding protein, Vitamin, Cholecalciferol, Parathyroid hormone, Internal medicine, Chemistry, Endocrinology, Calcium
- MeSH
- humans, vitamin d deficiency, vitamin d, reference standards, practice guidelines as topic, fibroblast growth factor-23, consensus statements as topic
12 authors
From US, NL, NO, BE, CA, AU, IT
- Christopher T. Sempos · correspondingGrace (United States)
- Annemieke C. HeijboerAmsterdam UMC Location University of Amsterdam; Amsterdam UMC Location Vrije Universiteit Amsterdam
- Daniel D. BikleSan Francisco VA Medical Center; University of California, San Francisco
- Jens BollerslevOslo University Hospital; University of Oslo
- Roger BouillonKU Leuven
- Patsy M. BrannonCornell University
Abstract
The First International Conference on Controversies in Vitamin D was held in Pisa, Italy, 14-16 June 2017. The meeting's purpose was to address controversies in vitamin D research, review the data available, to help resolve them, and suggest a research agenda to clarify areas of uncertainty. The serum 25-hydroxyvitamin D [25(OH)D] concentration [i.e. the sum of 25(OH)D3 and 25(OH)D2 ] remains the critical measurement for defining vitamin D status. Assay variation for 25(OH)D has contributed to the current chaos surrounding efforts to define hypovitaminosis D. An essential requirement to develop a consensus on vitamin D status is that measurement of 25(OH)D and, in the future, other potential vitamin D biomarkers [e.g. 1α,25(OH)2 D3 , 3-epi-25(OH)D, 24,25(OH)2 D3, vitamin D-binding protein, free/bioavailable 25(OH)D and parathyroid hormone] be standardized/harmonized, to allow pooling of research data. Vitamin D Standardization Program tools are described and recommended for standardizing 25(OH)D measurement in research. In the future, similar methodology, based on National Institute for Standards and Technology standard reference materials, must be developed for other candidate markers of vitamin D status. Failure to standardize/harmonize vitamin D metabolite measurements is destined to promulgate continued chaos. At this time, 25(OH)D values below 12 ng ml-1 (30 nmol l-1 ) should be considered to be associated with an increased risk of rickets/osteomalacia, whereas 25(OH)D concentrations between 20 ng ml-1 and 50 ng ml-1 (50-125 nmol l-1 ) appear to be safe and sufficient in the general population for skeletal health. In an effort to bridge knowledge gaps in defining hypovitaminosis D, an international study on rickets as a multifactorial disease is proposed.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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