The Effects of Music Intervention on Functional Connectivity Strength of the Brain in Schizophrenia
Yang M, He H, Duan M, Chen X, Chang X, Lai Y, Li J, Liu T, Luo C, Yao D
Neural plasticity · 29 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- Government
- National Natural Science Foundation of China
- Government
- Department of Science and Technology of Sichuan Province
- Government
- Health and Family Planning Commission of Sichuan Province Research Project
- Government
- National Key Scientific Instruments and Equipment Development of China
- Government
- Sichuan Province Science and Technology Support Project
- Government
- Chinese Fundamental Research Funding for Central Universities
- Grants
- National Natural Science Foundation of China (ZYGX2015J091); Department of Science and Technology of Sichuan Province (ZYGX2015J091); National Natural Science Foundation of China (16PJ051); Department of Science and Technology of Sichuan Province (16PJ051); National Natural Science Foundation of China (2013YQ490859); Department of Science and Technology of Sichuan Province (2013YQ490859); Department of Science and Technology of Sichuan Province (2017JY0094); Department of Science and Technology of Sichuan Province (2017SZ0004); Department of Science and Technology of Sichuan Province (81471638); National Natural Science Foundation of China (2017SZ0004); National Natural Science Foundation of China (81571759); National Natural Science Foundation of China (81471638); Department of Science and Technology of Sichuan Province (81571759); National Natural Science Foundation of China (2017JY0094)
Based on 6 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-01-01 · Neural Plast · vol. 2018 · pp. 1–10
- Publisher
- Hindawi Publishing Corporation
- Cited
- 39 citations · more than 86% of similar papers · 2.1× the field average
- References
- 50 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Functional Brain Connectivity Studies · Neuroscience and Music Perception · Neural dynamics and brain function
- Keywords
- Neurocognitive, Schizophrenia (object-oriented programming), Functional magnetic resonance imaging, Music therapy, Intervention (counseling), Psychology, Medicine, Psychological intervention, Cognition, Functional connectivity, Neuroscience, Psychiatry
- MeSH
- brain, nerve net, humans, magnetic resonance imaging, treatment outcome, music therapy, brain mapping, follow-up studies, schizophrenia, female, male
10 authors
From CN
- Mi YangUniversity of Electronic Science and Technology of China
- Hui HeUniversity of Electronic Science and Technology of China
- Mingjun DuanUniversity of Electronic Science and Technology of China
- Xi ChenUniversity of Electronic Science and Technology of China
- Xin Long ChangUniversity of Electronic Science and Technology of China
- Yongxiu LaiUniversity of Electronic Science and Technology of China
Abstract
Schizophrenia is often associated with behavior abnormality in the cognitive and affective domain. Music intervention is used as a complementary treatment for improving symptoms in patients with schizophrenia. However, the neurophysiological correlates of these remissions remain poorly understood. Here, we investigated the effects of music intervention in neural circuits through functional magnetic resonance imaging (fMRI) study in schizophrenic subjects. Under the standard care, patients were randomly assigned to music and non-music interventions (MTSZ, UMTSZ) for 1 month. Resting-state fMRI were acquired over three time points (baseline, 1 month, and 6 months later) in patients and analyzed using functional connectivity strength (FCS) and seed-based functional connection (FC) approaches. At baseline, compared with healthy controls, decreased FCS in the right middle temporal gyrus (MTG) was observed in patients. However, after music intervention, the functional circuitry of the right MTG, which was related with the function of emotion and sensorimotor, was improved in MTSZ. Furthermore, the FC increments were significantly correlated with the improvement of symptoms, while vanishing 6 months later. Together, these findings provided evidence that music intervention might positively modulate the functional connectivity of MTG in patients with schizophrenia; such changes might be associated with the observed therapeutic effects of music intervention on neurocognitive function. This trial is registered with ChiCTR-OPC-14005339.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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