A Case of Hailey-Hailey Disease Managed With Oral Magnesium Citrate and High-Dose Vitamin D3
Gu K, Silver S
Journal of cutaneous medicine and surgery · 9 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Case report (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-05-01 · J Cutan Med Surg · vol. 22 · issue 3 · pp. 362–364
- Publisher
- SAGE Publishing
- Cited
- 13 citations · more than 78% of similar papers · 1.0× the field average
- References
- 10 works
- Access
- Paywalled
- Research areas
- Genetic and rare skin diseases. · Cancer and Skin Lesions · Dermatologic Treatments and Research
- Keywords
- Medicine, Hailey–Hailey disease, Dermatology, Pemphigus, Pharmacology
- MeSH
- humans, pemphigus, benign familial, citric acid, organometallic compounds, cholecalciferol, adult, female, torso
2 authors
From CA
- Kaien Gu · correspondingUniversity of Manitoba
- Shane G. SilverUniversity of Manitoba
Abstract
Hailey-Hailey disease, or benign familial pemphigus, is a rare blistering disease originally described in 1939. The disease is due to an autosomal dominant mutation in the ATP2C1 gene on chromosome 3, which encodes for an adenosine triphosphate-dependent calcium pump in the Golgi apparatus whose function is to maintain intercellular calcium homeostasis. Common treatments for Hailey-Hailey disease involve calcineurin inhibitors, topical corticosteroids, topical or systemic antibiotics, topical antifungals, ablative lasers, or botulin toxin. In this case report, we highlight a unique case of Hailey-Hailey disease that was resistant to many conventional therapies and ultimately managed with oral magnesium citrate and high-dose vitamin D3.
Abstract via Europe PMC. Copyright remains with the authors or publisher.
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