Cholecalciferol Injections Are Effective in Hypovitaminosis D After Duodenal Switch: a Randomized Controlled Study
Hultin H, Stevens K, Sundbom M
Obesity surgery · 6 citations
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
Who paid for it
- Funding
- Independent funding
- University or hospital
- Uppsala Universitet
- University or hospital
- Uppsala University
Based on 2 listed funder(s) and full-text disclosure statement.
Publication
- Published
- 2018-06-04 · Obes Surg · vol. 28 · issue 10 · pp. 3007–3011
- Publisher
- Springer Science+Business Media
- Cited
- 9 citations · more than 64% of similar papers · 0.4× the field average
- References
- 25 works
- Access
- Open access (hybrid journal) · CC-BY
- Research areas
- Bariatric Surgery and Outcomes · Vitamin D Research Studies · Parathyroid Disorders and Treatments
- Keywords
- Medicine, Cholecalciferol, Vitamin D and neurology, Duodenal switch, vitamin D deficiency, Internal medicine, Biliopancreatic Diversion, Population, Parathyroid hormone, Vitamin, Endocrinology, Gastroenterology, Weight loss, Obesity, Morbid obesity, Calcium
- MeSH
- humans, vitamin d deficiency, obesity, morbid, cholecalciferol, anastomosis, surgical, bariatric surgery
3 authors
From SE
- Hella HultinUppsala University
- Katharina StevensUppsala University
- Magnus Sundbom · correspondingUppsala University
Abstract
Background
By treating obesity, one of the major epidemics of this past century, through bariatric surgery, we may cause complications due to malnourishment in a growing population. At present, vitamin D deficiency is of interest, especially in patients with inferior absorption of fat-soluble nutrients after biliopancreatic diversion with duodenal switch (BPD/DS).
Methods
Twenty BPD/DS patients, approximately 4 years postoperatively, were randomized to either intramuscular supplementation of vitamin D with a single dose of 600,000 IU cholecalciferol, or a control group. Patients were instructed to limit their supplementation to 1400 IU of vitamin D and to avoid the influence of UV-B radiation; the study was conducted when sunlight is limited (December to May).
Results
Despite oral supplementation, a pronounced deficiency in vitamin D was seen (injection 19.3; control 23.2 nmol/l) in both groups. The cholecalciferol injection resulted in elevated 25[OH]D levels at 1 month (65.4 nmol/l), which was maintained at 6 months (67.4 nmol/l). This resulted in normalization of intact parathyroid hormone (PTH) levels. No changes in vitamin D or PTH occurred in the control group.
Conclusions
In BPD/DS patients, having hypovitaminosis D despite full oral supplementation, a single injection of 600,000 IU of cholecalciferol was effective in elevating vitamin D levels and normalizing levels of intact PTH. The treatment is simple and highly effective and thus recommended, especially in cases of reduced UV-B radiation.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.