Dietary cholesterol intake and stroke risk: a meta-analysis
Cheng P, Pan J, Xia J, Huang W, Bai S, Zhu X, Shao W, Wang H, Xie P, Deng F
Oncotarget · 9 citations
How it was studied
- Design
- Meta-analysis (classified by our AI screen)
- Studied in
- People
- Main outcome
- Clinical events such as disease or death
- Intake measured by
- Not stated
Who paid for it
- Funding
- Independent funding
- Government
- Natural Science Foundation of Heilongjiang Province
- Government
- Health and Family Planning Commission of Heilongjiang Province
- University or hospital
- Jiamusi University
- Government
- National Key Research and Development Program of China
- Grants
- Natural Science Foundation of Heilongjiang Province (H2016087); National Key Research and Development Program of China (2009CB918300)
Based on 4 listed funder(s).
Publication
- Published
- 2018-01-04 · Oncotarget · vol. 9 · issue 39 · pp. 25698–25707
- Publisher
- Impact Journals LLC
- Cited
- 24 citations · more than 39% of similar papers · 0.2× the field average
- References
- 64 works
- Access
- Open access (free to publish) · CC-BY
- Research areas
- Nutritional Studies and Diet · Lipoproteins and Cardiovascular Health · Cholesterol and Lipid Metabolism
- Keywords
- China, Medicine, Neurology, Stroke (engine), Family medicine, Traditional medicine, Psychiatry, Geography
10 authors
From CN
- Pengfei Cheng · correspondingFirst Affiliated Hospital of Jiamusi University; The Affiliated Yongchuan Hospital of Chongqing Medical University; Chongqing Medical University
- Junxi Pan · correspondingChongqing Medical University
- Jinjun Xia · correspondingChongqing Medical University
- Fengli Deng · correspondingChongqing Medical University
- Wen Cheng HuangArmy Medical University; Xinqiao Hospital
- Shunjie BaiChongqing Medical University
Abstract
Background/objectives
The association between dietary cholesterol and stroke risk has remained controversial over the past two decades. The aim of this meta-analysis was to assess the relationship between dietary cholesterol and stroke risk.
Results
Seven prospective studies including 269,777 non-overlapping individuals (4,604 strokes) were included. The combined RR of stroke for higher cholesterol intake (> 300 mg/day) was 0.98 (95% CI, 0.90-1.07), and the combined RR of stroke for higher cholesterol intake (> 300 mg/day) in females (age of ≥ 60 years or body mass index of ≥ 24 kg/m2) was 1.18 (95% CI, 1.02-1.36).
Materials and methods
The PubMed, Medline, Embase, Web of Knowledge, and Google Scholar databases were searched. Relevant studies were identified by searching these online databases through September 2017. The relative risk (RR) and 95% confidence interval (CI) were used to investigate the strength of the association.
Conclusions
Higher cholesterol intake has no association with the overall stroke risk. Age and body mass index affect the relationship between dietary cholesterol intake and stroke risk. However, the association between higher dietary cholesterol and stroke risk in males remains unclear.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
Community trust
Loading…
How much do you trust this study's findings?
Comments
Sign in to rate, comment on or flag this study.Sign inSomething wrong here?
Flag this study if its information, labels or funding look wrong. An editor reviews every flag.
Sign in to rate, comment on or flag this study.Sign inEducational information about published research. Not medical advice, and not a recommendation to start or stop anything.