A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults
Whyte AR, Cheng N, Fromentin E, Williams CM
Nutrients · 103 citations
Review labels
Neutral facts our review recorded about how this study was done. They describe method, never whether we like the result.
How it was studied
- Design
- Randomized controlled trial (indexed by PubMed)
- Studied in
- People
- Main outcome
- Health markers and function
- Intake measured by
- Not stated
Who paid for it
- Funding
- Funding not disclosed
Publication
- Published
- 2018-05-23 · Nutrients · vol. 10 · issue 6 · p. 660
- Publisher
- Multidisciplinary Digital Publishing Institute
- Cited
- 128 citations · more than 99% of similar papers · 8.4× the field average
- Impact
- Top 10% most cited in its field
- References
- 42 works
- Access
- Open access (journal) · CC-BY
- Research areas
- Dementia and Cognitive Impairment Research · Medicinal Plants and Neuroprotection · Neurological Disease Mechanisms and Treatments
- Keywords
- Placebo, Randomized controlled trial, Episodic memory, Population, Medicine, Working memory, Mood, Cognitive decline, Effects of sleep deprivation on cognitive performance, Cognition, Blood pressure, Physical therapy, Audiology, Internal medicine, Clinical psychology, Psychiatry, Dementia, Pathology
- MeSH
- humans, fruit, nootropic agents, plant extracts, powders, treatment outcome, phytotherapy, geriatric assessment, double-blind method, affect, cognition, memory, short-term, neuropsychological tests, age factors, time factors, aged, aged, 80 and over, england, female, male, executive function, memory, episodic, cognitive aging, blueberry plants
4 authors
From GB, US
- Adrian Robert WhyteUniversity of Reading
- Nancy ChengUniversity of Reading
- Emilie FromentinThe Nature Conservancy
- Claire Michelle Williams · correspondingUniversity of Reading
Abstract
Previous research has shown beneficial effects of polyphenol-rich diets in ameliorating cognitive decline in aging adults. Here, using a randomized, double blinded, placebo-controlled chronic intervention, we investigated the effect of two proprietary blueberry formulations on cognitive performance in older adults; a whole wild blueberry powder at 500 mg (WBP500) and 1000 mg (WBP1000) and a purified extract at 100 mg (WBE111). One hundred and twenty-two older adults (65⁻80 years) were randomly allocated to a 6-month, daily regimen of either placebo or one of the three interventions. Participants were tested at baseline, 3, and 6 months on a battery of cognitive tasks targeting episodic memory, working memory and executive function, alongside mood and cardiovascular health parameters. Linear mixed model analysis found intervention to be a significant predictor of delayed word recognition on the Reys Auditory Verbal Learning Task (RAVLT), with simple contrast analysis revealing significantly better performance following WBE111 at 3 months. Similarly, performance on the Corsi Block task was predicted by treatment, with simple contrast analysis revealing a trend for better performance at 3 months following WBE111. Treatment also significantly predicted systolic blood pressure (SBP) with simple contrast analysis revealing lower SBP following intervention with WBE111 in comparison to placebo. These results indicate 3 months intervention with WBE111 can facilitate better episodic memory performance in an elderly population and reduce cardiovascular risk factors over 6 months.
Abstract via Europe PMC. Copyright remains with the authors or publisher (CC BY).
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